A meta analysis on risks of adverse pregnancy outcomes in Toxoplasma gondii infection.
A meta analysis on risks of adverse pregnancy outcomes in Toxoplasma gondii infection.
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弓形虫感染不良妊娠结局风险的荟萃分析
DOI：
10.1371/journal.pone.0097775
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Lindsay DS
中科院分区：
文献类型：
--
作者：
Li XL;Wei HX;Zhang H;Peng HJ;Lindsay DS
目的对国内外已发表的弓形虫先天性感染及母体感染后不良妊娠结局的风险进行Meta分析。方法检索多个文献数据库的相关文献，不分语种。采用优势比（OR）和95%可信区间（CI）评价弓形虫母婴垂直传播和异常妊娠结局的风险。结果共检索到2632篇文献，其中53篇纳入分析。T.弓形虫感染孕妇（感染组）与未感染孕妇（对照组）比较，差异有统计学意义（OR = 5.10，95% CI，3.85-6.75）。 妊娠结局异常组弓形虫感染率显著高于妊娠结局正常组（OR = 3.71，95% CI，3.31-4.15）。 母亲感染T.的合并垂直传播率为20%（95%CI，15%-26%）。刚地在妊娠早期、中期和晚期感染的妇女中垂直传播的发生率分别为5%（95%CI，2%-16%）、13%（95%CI，7%-23%）和32%（95%CI，24%-41%）。单用螺旋霉素、PSF（乙胺嘧啶+磺胺嘧啶+亚叶酸）或PS（乙胺嘧啶+磺胺嘧啶）联合螺旋霉素或其他非典型治疗的妇女垂直传播率分别为13%（95%CI，7%-22%）、13%（95%CI，7%-25%）和24%（95%CI，18%-32%）。结论孕妇弓形虫感染可导致不良妊娠结局。母婴垂直传播率为20%，在妊娠早期、中期和晚期垂直传播的发生率增加。在仅用螺旋霉素、PSF或PS联合螺旋霉素或其他非典型治疗组中，合并传播率无显著差异。
Objective Quantified risks of congenital Toxoplasma gondii infection and abnormal pregnancy outcomes following primary maternal infection were evaluated with meta- analysis based on published studies. Methods The related literatures were searched in multiple literature databases regardless of languages. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the risks of vertical transmission of Toxoplasma gondii and abnormal pregnancy outcomes following primary maternal infection with meta-analysis. Results 53 of the 2632 searched literatures were included in our analysis. The incidence of abnormal pregnancy outcomes in T. gondii infected pregnant women (infected group) was significantly higher than that in the uninfected pregnant women (control group) (OR = 5.10; 95% CI, 3.85–6.75). Toxoplasma gondii infection rate in the abnormal-pregnancy-outcome group was significantly higher than in the normal-pregnancy group (OR = 3.71; 95% CI, 3.31–4.15). The pooled rate of vertical transmission was 20% (95% CI, 15%–26%) in maternal infection of T. gondii. The incidences of vertical transmission in women who were infected in the first, second or third trimester of pregnancy were 5% (95%CI, 2%–16%), 13% (95%CI, 7%–23%), and 32% (95%CI, 24%–41%), respectively. The rates of vertical transmission in women who were treated with spiramycin-only, PSF (pyrimethamine + sulfadiazine + folinic acid) or PS (pyrimethamine + sulfadiazine) combined with spiramycin, or other untypical treatments were 13% (95%CI, 7%–22%), 13%(95%CI, 7%–25%), and 24%(95%CI, 18%–32%), respectively. Conclusions Toxoplasma gondii infection can result in adverse pregnancy outcomes in pregnant women. The pooled rate of vertical transmission was 20% in maternal infection and the incidences of vertical transmission increased in the first, second or third trimester of pregnancy. The pooled rates of transmission in groups treated with spiramycin-only, PSF or PS combined with spiramycin, or other untypical treatments were not significantly different.
影响因子：
3
作者：
Antsaklis, A;Daskalakis, G;Michalas, S
通讯作者：
Michalas, S