Mechanical Forces and Growth in Animal Tissues
Mechanical Forces and Growth in Animal Tissues
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DOI：
10.1101/cshperspect.a019232
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发表时间：
2016-03-01
影响因子：
7.2
通讯作者：
Lecuit, Thomas
中科院分区：
文献类型：
--
作者：
LeGoff, Loic;Lecuit, Thomas
机械力塑造生物组织。它们是协调形态发生的发育程序的效应者。许多人致力于从力学的角度来理解形态发生过程。在这篇综述中，我们着重于组织力学和生长之间的相互作用。我们首先描述组织力学如何通过影响细胞分裂的方向和控制体积增加和增殖速度的信号通路来影响生长。然后，我们讨论组织的机械状态如何受到生长模式的影响。如果我们想要了解组织是如何生长和塑造自己的，就必须以一种综合的方式研究生长和力学之间的正向和反向相互作用。为了说明这一点，我们描述了通过使用机械力的反馈机制来实现生长动态平衡的例子。
Mechanical forces shape biological tissues. They are the effectors of the developmental programs that orchestrate morphogenesis. A lot of effort has been devoted to understanding morphogenetic processes in mechanical terms. In this review, we focus on the interplay between tissue mechanics and growth. We first describe how tissue mechanics affects growth, by influencing the orientation of cell divisions and the signaling pathways that control the rate of volume increase and proliferation. We then address how the mechanical state of a tissue is affected by the patterns of growth. The forward and reverse interactions between growth and mechanics must be investigated in an integrative way if we want to understand how tissues grow and shape themselves. To illustrate this point, we describe examples in which growth homeostasis is achieved by feedback mechanisms that use mechanical forces.