Electrophysiological evidence for detrimental impact of a reappraisal emotion regulation strategy on subsequent cognitive control in schizophrenia.
Electrophysiological evidence for detrimental impact of a reappraisal emotion regulation strategy on subsequent cognitive control in schizophrenia.
复制标题
重新评估情绪调节策略对精神分裂症后续认知控制产生不利影响的电生理学证据。
DOI：
10.1037/abn0000285
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发表时间：
2017
影响因子：
4.6
通讯作者：
Strauss,GregoryP
中科院分区：
文献类型：
--
作者：
Sullivan,SaraK;Strauss,GregoryP
在健康个体中，有证据表明，有效实施情绪调节策略对时间上最近的认知控制任务表现具有有益影响。出现这种效应是因为这两个过程都严重依赖前额叶皮层。精神分裂症 (SZ) 患者的情绪调节和认知控制均存在缺陷，这是由前额皮质的结构和功能异常引起的；然而，目前尚不清楚情绪调节尝试是否无法使精神分裂症患者随后执行的认知控制任务受益。本研究探讨了通过重新评估尝试增加或减少负面情绪是否对诊断为 SZ 的门诊患者样本 (n = 30) 和人口统计学匹配的健康对照样本 (CN; n = 29) 的后续认知控制有不同的影响。参与者完成了一项综合情绪调节和认知控制任务，其中在不愉快或中性图像之后立即呈现数字斯特鲁普试验，这些图像要么通过重新评估而增加，要么通过重新评估而减少，或被动观看。在参与者执行重新评估-斯特鲁普任务时记录脑电图，并使用事件相关电位（ERP）来索引情绪调节有效性（晚期正电位：LPP）和认知控制（持续电位：SP）。 CN 和 SZ 均表现出对不愉快刺激的 LPP 振幅高于中性刺激，这与对不愉快刺激的强烈神经反应一致。尽管 CN 证明了有效使用重新评估来增加和减少负面情绪的神经生理学证据，但 SZ 仅显示出通过重新评估有效增加负面情绪的能力。 CN 在增加试验后表现出增强的认知控制，在减少试验后表现出认知控制受损，如 SP 幅度的调节所示。在 SZ 中，增加指令会损害认知控制，而减少指令对认知控制没有影响。研究结果表明，情绪调节异常可能在精神分裂症发生的一般认知控制缺陷中发挥着未被充分认识的作用。
In healthy individuals, there is evidence that effective implementation of an emotion regulation strategy has beneficial effects on temporally proximal cognitive control task performance. This effect occurs because both of these processes rely heavily on the prefrontal cortex. Individuals with schizophrenia (SZ) have impairments in both emotion regulation and cognitive control that are driven by structural and functional abnormalities of the prefrontal cortex; however, it is unknown whether emotion regulation attempts fail to benefit subsequently performed cognitive control tasks in people with SZ. The present study examined whether attempts to increase or decrease negative emotion via reappraisal have differential effects on subsequent cognitive control in a sample of outpatients diagnosed with SZ (n= 30) and demographically matched healthy controls (CN; n= 29). Participants completed a combined emotion regulation and cognitive control task in which numerical Stroop trials were presented immediately after unpleasant or neutral images that were either increased via reappraisal, decreased via reappraisal, or passively viewed. The electroencephalogram was recorded while participants performed the reappraisal-Stroop task and event related potentials (ERPs) were used to index emotion regulation effectiveness (late positive potential: LPP) and cognitive control (sustained potential: SP). Both CN and SZ evidenced higher LPP amplitude for unpleasant than neutral stimuli consistent with robust neural response to unpleasant stimuli. Although CN demonstrated neurophysiological evidence of effective use of reappraisal to increase and decrease negative emotion, SZ only showed an effective ability to increase negative emotion via reappraisal. CN displayed enhanced cognitive control following increase trials and impaired cognitive control following decrease trials, as indicated by modulation of SP amplitude. In SZ, increase instructions impaired cognitive control and decrease instructions had no effect on cognitive control. Findings suggest that emotion regulation abnormalities may play an underrecognized role in general cognitive control deficits that occur in SZ.