Induction of LTP in the human auditory cortex by sensory stimulation
Induction of LTP in the human auditory cortex by sensory stimulation
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DOI：
10.1111/j.1460-9568.2005.04293.x
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发表时间：
2005-09-01
影响因子：
3.4
通讯作者：
Teyler, TJ
中科院分区：
文献类型：
--
作者：
Clapp, WC;Kirk, IJ;Teyler, TJ
高频，重复，听觉刺激被用来确定是否诱导一个持久的增加人类听觉诱发电位（AEP）是可能的。用脑电图头皮电极非侵入性地记录，在AEP的N1分量中观察到幅度的稳定增加，这被认为反映了听觉皮层（N1）内的活动。这种增加持续了一个多小时，并且被证明与唤醒状态的改变无关。这是第一个演示的诱导持久的可塑性变化的AEPs，并建议，这是第一次直接演示的长时程增强在正常的，完整的人类听觉皮层。
High-frequency, repetitive, auditory stimulation was used to determine whether induction of a long-lasting increase of the human auditory evoked potential (AEP) was possible. Recording non-invasively with electroencephalogram scalp electrodes, stable increases in amplitude were observed in the N1 component of the AEP, which is thought to reflect activity within auditory cortex (N1). The increase was maintained over an hour and was shown to be independent of alterations in the state of arousal. This is the first demonstration of the induction of long-lasting plastic changes in AEPs, and suggest that this represents the first direct demonstration of long-term potentiation in the auditory cortex of normal, intact humans.