Cerebral blood flow in immediate and sustained anxiety
Cerebral blood flow in immediate and sustained anxiety
复制标题
DOI：
10.1523/jneurosci.5369-06.2007
复制
发表时间：
2007-06-06
影响因子：
5.3
通讯作者：
Grillon, Christian
中科院分区：
文献类型：
--
作者：
Hasler, Gregor;Fromm, Stephen;Grillon, Christian
本研究的目的是比较脑血流量（CBF）的变化与阶段性线索恐惧与持续的背景焦虑。使用[O-15] H（2）0在17名健康人类受试者中获得CBF的正电子发射断层扫描图像，因为他们预期可预测（通过视觉提示发出信号）或不可预测（受到环境威胁）的不愉快电击。在任何一种威胁条件下，提示的呈现都与左杏仁核CBF的增加有关。一个特别预测休克的线索与腹侧前额叶皮质（PFC）、下丘脑、前扣带回皮质、左丘脑和双侧壳核的CBF增加有关。持续的威胁情境增加了右侧海马、扣带回中部、膝下PFC、中脑导水管周围灰质、丘脑、双侧腹侧纹状体和顶枕叶皮质的CBF。这项研究表明，不同的神经元网络参与线索恐惧和背景焦虑的重要性，这种区别的研究焦虑症的病理生理。
The goal of this study was to compare cerebral blood flow (CBF) changes associated with phasic cued fear versus those associated with sustained contextual anxiety. Positron emission tomography images of CBF were acquired using [O-15] H(2)0 in 17 healthy human subjects as they anticipated unpleasant electric shocks that were administered predictably (signaled by a visual cue) or unpredictably (threatened by the context). Presentation of the cue in either threat condition was associated with increased CBF in the left amygdala. A cue that specifically predicted the shock was associated with CBF increases in the ventral prefrontal cortex (PFC), hypothalamus, anterior cingulate cortex, left insula, and bilateral putamen. The sustained threat context increased CBF in the right hippocampus, mid-cingulate gyrus, subgenual PFC, midbrain periaqueductal gray, thalamus, bilateral ventral striatum, and parieto-occipital cortex. This study showed distinct neuronal networks involved in cued fear and contextual anxiety underlying the importance of this distinction for studies on the pathophysiology of anxiety disorders.