Exploiting nucleobase-containing materials - from monomers to complex morphologies using RAFT dispersion polymerization
Exploiting nucleobase-containing materials - from monomers to complex morphologies using RAFT dispersion polymerization
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DOI：
10.1039/c4py01074d
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发表时间：
2015-01-07
影响因子：
4.6
通讯作者：
O'Reilly, Rachel K.
中科院分区：
文献类型：
--
作者：
Kang, Yan;Pitto-Barry, Anais;O'Reilly, Rachel K.
在氯仿和1，4-二氧六环中，通过RAFT分散聚合成功地合成了含核碱基的聚合物，并诱导了聚合物的自组装。散射和显微镜技术的组合被用来表征的形态。研究发现，自组装含核碱基聚合物的形貌是溶剂依赖性的。通过改变核形成嵌段的DP，当仅使用含腺嘌呤的甲基丙烯酸酯或含腺嘌呤的甲基丙烯酸酯和含胸腺嘧啶的甲基丙烯酸酯的混合物作为单体时，在氯仿中仅获得具有内部结构的球形胶束。然而，在1，4-二氧六环中观察到了更高级的结构和形态转变。在这项研究中观察到的球棒片层扭曲的双层转变。此外，在这两种溶剂中的分散聚合的动力学进行了研究，表明在这些系统中的不同的形成机制。
The synthesis of nucleobase-containing polymers was successfully performed by RAFT dispersion polymerization in both chloroform and 1,4-dioxane and self-assembly was induced by the polymerizations. A combination of scattering and microscopy techniques were used to characterize the morphologies. It is found that the morphologies of self-assembled nucleobase-containing polymers are solvent dependent. By varying the DP of the core-forming block, only spherical micelles with internal structures were obtained in chloroform when using only adenine-containing methacrylate or a mixture of adenine-containing methacrylate and thymine-containing methacrylate as monomers. However, higher order structures and morphology transitions were observed in 1,4-dioxane. A sphere-rod-lamella-twisted bilayer transition was observed in this study. Moreover, the kinetics of the dispersion polymerizations were studied in both solvents, suggesting a different formation mechanism in these systems.