THE ENDOCRINOLOGY OF THE MENOPAUSAL TRANSITION - A CROSS-SECTIONAL STUDY OF A POPULATION-BASED SAMPLE
THE ENDOCRINOLOGY OF THE MENOPAUSAL TRANSITION - A CROSS-SECTIONAL STUDY OF A POPULATION-BASED SAMPLE
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DOI：
10.1210/jc.80.12.3537
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发表时间：
1995-12-01
影响因子：
5.8
通讯作者：
MORSE, C
中科院分区：
文献类型：
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作者：
BURGER, HG;DUDLEY, EC;MORSE, C
在一项围绝经期内分泌学研究中，对 380 名女性（平均年龄 49.4 岁；范围 45.6-56.9 岁）的人群样本中的血清 FSH、雌二醇 (E(2))、免疫反应性抑制素 (INH)、睾酮和性激素结合球蛋白水平进行了测量。受试者被分为以下几类：月经周期持续规律的女性（27%；第一组）、月经流量变化但频率没有变化的女性（23%；第二组）、频率变化但流量没有变化的女性（9%；第三组）、频率和流量均发生变化的女性（28%；第四组）以及距末次月经至少 3 个月（13%；第五组）。调整年龄和体重指数后，各月经组的 FSH 几何平均值均有所增加，与 I 组相比，IV 组高出 53%（P < 0.0005），V 组高出 253%（P < 0.0001）。 V 组中 E(2) 和 INH 的年龄和体重指数调整几何平均值分别为第 1 组的 54% 和 53%（P < 0.005，P < 0.0001）。与随后至少再有一次月经的女性相比，第二年没有月经的 V 组女性的 FSH 较高，E(2) 和 INH 水平较低（P < 0.05）。 FSH 与 E(2) (r = -0.30) 和 INH (r = -0.39) 呈负相关，而 INH 与 E(2) (r = 0.45) 呈正相关。我们得出的结论是，血清 FSH 的增加以及 E(2) 和 INH 的减少是与绝经过渡相关的主要内分泌变化。
In a study of the endocrinology of the perimenopausal years, levels of serum FSH, estradiol (E(2)), immunoreactive inhibin (INH), testosterone, and sex hormone-binding globulin were measured in a population-based sample of 380 women (mean age, 49.4 yr; range, 45.6-56.9 yr). Subjects were divided into women who reported continuing regular menstrual cycles (27%; group I), a change in menstrual flow without a change in frequency (23%; group II), a change in frequency but no change in flow (9%; group III), changes in both frequency and flow (28%; group IV), and at least 3 months since their last menstrual period (13%; group V). After adjusting for age and body mass index, the geometric mean FSH increased across menstrual groups and, compared with group I, was 53% higher in group IV (P < 0.0005) and 253% higher in group V (P < 0.0001). Age- and body mass index-adjusted geometric means for E(2) and INH in group V were 54% and 53% of those in group 1, respectively (P < 0.005, P < 0.0001). Women in group V who did not have a menstrual period in the next year had higher FSH and lower E(2) and INH levels than those who subsequently went on to have at least one more menstrual period (P < 0.05). FSH was negatively correlated with E(2) (r = -0.30) and INH (r = -0.39), whereas INH was positively correlated with E(2) (r = 0.45). We conclude that an increase in serum FSH and decreases in E(2) and INH are the major endocrine changes associated cross-sectionally with the menopausal transition.