A Voxel-Based Morphometry Study of Frontal Gray Matter Correlates of Impulsivity
A Voxel-Based Morphometry Study of Frontal Gray Matter Correlates of Impulsivity
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DOI：
10.1002/hbm.20588
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发表时间：
2009-04-01
影响因子：
4.8
通讯作者：
Soares, Jair C.
中科院分区：
文献类型：
--
作者：
Matsuo, Koji;Nicoletti, Mark;Soares, Jair C.
冲动是健康人的一种人格特征，但过度冲动与一些精神障碍有关。病变和功能，神经影像学研究表明，腹内侧前额叶区（VMPFC），包括眶额皮质（OFC），前扣带皮质（ACC）和内侧前额叶皮质，杏仁核可能调节冲动和攻击。然而，没有形态计量学研究检验VMPFC和冲动性之间的关系。我们假设，具有高冲动性的健康受试者在这些大脑区域的体积比具有低冲动性的受试者要小。使用1.5 t MRI系统对62名健康受试者（年龄35.4±12.1岁）进行了研究。采用Barratt冲动性量表（BIS）评估冲动性。使用优化的基于体素的形态测量（VBM）协议处理图像。我们计算了BIS评分与VMPFC和杏仁核灰质（GM）和白质（WM）体积之间的相关性。左、右OFC GM体积与BIS总分呈负相关（P分别为0.04和0.02）。左侧ACC GM容积与BIS总分呈负相关（P = 0.05）。右侧OFC GM体积与BIS非计划性冲动性呈负相关，左侧OFC GM体积与运动冲动性呈负相关。WM体积与冲动性无显著相关性。本形态学研究结果表明，小OFC体积与高冲量有关，并扩展了先前的发现，即VMPFC参与调制冲量的电路。中国生物医学工程学报（英文版），2009。(C) 2008 Wiley-Liss, Inc。
Impulsivity is a personality trait exhibited by healthy individuals, but excessive impulsivity is associated with some mental disorders. Lesion and functional, neuroimaging Studies indicate that the ventromedial prefrontal region (VMPFC), including the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC) and medial prefrontal cortex, and the amygdala may modulate impulsivity and aggression. However, no morphometric study has examined the association between VMPFC and impulsivity. We hypothesized that healthy subjects with high impulsivity would have smaller volumes in these brain regions compared with those with low impulsivity. Sixty-two healthy Subjects were Studied (age 35.4 +/- 12.1 years) using a 1.5-T MRI system. The Barratt impulsiveness scale (BIS) was used to assess impulsivity. Images were processed using an optimized voxel-based morphometry (VBM) protocol. We calculated the correlations between BIS scale scores and the gray matter (GM) and white matter (WM) volumes of VMPFC and amygdala. GM volumes of the left and right OFC were inversely correlated with the BIS total score (P = 0.04 and 0.02, respectively). Left ACC GM Volumes had a tendency to be inversely correlated with the BIS total score (P = 0.05. Right OFC GM Volumes were inversely correlated with BIS nonplanning impulsivity, and left OFC GM volumes were inversely correlated with motor impulsivity. There were no significant WM volume correlations with impulsivity. The results Of this morphometry Study indicate that small OFC volume relate to high impulsivity and extend the prior finding that the VMPFC is involved in the circuit modulating impulsivity. HUM Brain Mapp 30:1188-1195, 2009. (C) 2008 Wiley-Liss, Inc.