Human Oral Motion‐Powered Smart Dental Implant (SDI) for In Situ Ambulatory Photo‐biomodulation Therapy
Human Oral Motion‐Powered Smart Dental Implant (SDI) for In Situ Ambulatory Photo‐biomodulation Therapy
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DOI：
10.1002/adhm.202000658
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发表时间：
2020-07
影响因子：
10
通讯作者：
Moonchul Park;Sayemul Islam;Hye-Eun Kim;J. Korostoff;M. Blatz;G. Hwang;Albert Kim
中科院分区：
文献类型：
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作者：
Moonchul Park;Sayemul Islam;Hye-Eun Kim;J. Korostoff;M. Blatz;G. Hwang;Albert Kim
种植体周围疾病是一种影响牙科种植体周围软硬组织的炎症性疾病。然而，目前的预防方法是不够的，由于有限的生物活性的牙种植体和病人的依从性差。最近，可以恢复和再生种植体软组织的光生物调节（PBM）疗法在牙科中引起了相当大的关注。在本文中，一种无缝的人类口腔运动动力牙科种植体系统（称为智能牙科种植体或SDI）作为一种非卧床PBM治疗模式。SDI允许原位光传输，这是通过经由工程压电牙冠、相关电路和微型发光二极管（LED）从动态人类口腔运动（咀嚼和刷牙）中收集能量来实现的。SDI还提供了足够的机械强度作为临床标准。使用原代人牙龈角质形成细胞（HGK）作为模型宿主生物体，铜绿假单胞菌脂多糖（LPS）作为模型炎症刺激物，证明了有效的SDI介导的PBM治疗。一种新型的牙科种植体可能是一种非卧床PBM治疗平台，用于预防种植体疾病，而无需患者依赖性，从而保护持久的牙科种植体。
Peri‐implant disease is an inflammatory condition affecting the soft and hard tissues surrounding a dental implant. However, current preventative methods are insufficient due to the limited bioactivity on the dental implant and poor patient compliance. Recently, photo‐biomodulation (PBM) therapy that can recover and regenerate peri‐implant soft tissue has attracted considerable attention in dentistry. In this paper, a seamless human oral motion‐powered dental implant system (called Smart Dental Implant or SDI) is presented as an ambulatory PBM therapy modality. SDI allows the in situ light delivery, which is enabled by the energy harvesting from dynamic human oral motions (chewing and brushing) via an engineered piezoelectric dental crown, an associated circuit, and micro light emitting diodes (LEDs). The SDI also offers adequate mechanical strength as the clinical standards. Using primary human gingival keratinocytes (HGKs) as a model host organism and Pseudomonas aeruginosa lipopolysaccharides (LPS) as a model inflammatory stimulus, effective SDI‐mediated PBM therapy is demonstrated. A new class of dental implants could be an ambulatory PBM therapy platform for the prevention of peri‐implant disease without patient dependency, warranting long‐lasting dental implants.