Comparison of Longitudinal Skeletal Thigh Muscle Findings With Magnetic Resonance Imaging in Patients With Peripheral Artery Disease With-Versus-Without Diabetes Mellitus.
Comparison of Longitudinal Skeletal Thigh Muscle Findings With Magnetic Resonance Imaging in Patients With Peripheral Artery Disease With-Versus-Without Diabetes Mellitus.
复制标题
患有或不患有糖尿病的外周动脉疾病患者的纵向骨骼大腿肌肉的磁共振成像结果的比较。
DOI：
10.1016/j.amjcard.2022.06.060
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Brunner,Gerd
中科院分区：
文献类型：
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作者：
Gimnich,OlgaA;Ortiz,CarlosB;Yang,EricY;Chen,Changyi;Virani,SalimS;Kougias,Panos;Lumsden,AlanB;Morrisett,JoelD;Ballantyne,ChristieM;Nambi,Vijay;Brunner,Gerd
对ELIMIT（血管内干预试验后脂质修饰对外周动脉疾病的影响）进行二次分析的目的是确定伴有和不伴有糖尿病的外周动脉疾病（PAD）患者24个月内骨骼肌体积和单个肌肉室的纵向变化。本分析共纳入48例基线和2年内可获得远端股浅动脉磁共振成像的患者。量化肌肉体积、股浅动脉壁、管腔和总血管体积。采用双向模型，用类内相关系数评估阅读器内肌肉描记的可重复性。除了吸烟史（p = 0.049）、胆固醇水平（p <0.050）和小腿行走疼痛（p = 0.049）外，伴有和不伴有糖尿病的PAD患者的基线特征相似。所有肌肉群的肌肉体积追踪的观察者间再现性都很好（所有类内相关系数>0.86，置信区间0.69至0.94）。无糖尿病的PAD患者的总肌肉和总腿部体积在基线和24个月之间显著增加（31±6.4 cm3vs 32±7.0 cm3, p <0.001; 18±4.4 cm3vs 19±4.8 cm3, p = 0.045），而伴有PAD和糖尿病的患者没有变化。无论是否伴有糖尿病，PAD患者的总肌肉体积与年龄和体重指数呈负相关（p <0.05）。总之，磁共振成像量化的大腿肌肉体积具有高度可重复性，可能对评估伴有或不伴有糖尿病的PAD患者有意义。
The aim of this secondary analysis of ELIMIT (The Effect of Lipid Modification on Peripheral Artery Disease after Endovascular Intervention Trial) was to determine longitudinal changes over 24 months in skeletal thigh muscle volumes and individual muscle compartments in patients with peripheral artery disease (PAD) with and without diabetes. A total of 48 patients with available magnetic resonance imaging of the distal superficial femoral artery at baseline and 2 years were included in this analysis. Muscle volumes and superficial femoral artery wall, lumen, and total vessel volumes were quantified. Intrareader reproducibility of muscle tracings was assessed with the intraclass correlation coefficient using a 2-way model. Baseline characteristics were similar between patients with PAD with and without diabetes, except for smoking history (p = 0.049), cholesterol levels (p <0.050), and calf walking pain (p = 0.049). Interobserver reproducibility of the muscle volume tracings was excellent for all muscle groups (all intraclass correlation coefficients >0.86, confidence interval 0.69 to 0.94). Total muscle and total leg volumes increased significantly between baseline and 24 months among patients with PAD without diabetes (31 ± 6.4 cm3vs 32 ± 7.0 cm3, p <0.001; 18 ± 4.4 cm3vs 19 ± 4.8 cm3, p = 0.045), whereas there was no change in patients with PAD and diabetes. Total muscle volume was inversely associated with age and body mass index in patients with PAD both with and without diabetes (p <0.05). In conclusion, magnetic resonance imaging–quantified thigh muscle volumes are highly reproducible and may be of interest in assessing PAD patients with and without diabetes.