[Fundamental aspects of synthetic biology].
[Fundamental aspects of synthetic biology].
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DOI：
10.13345/j.cjb.160477
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发表时间：
2017-03
期刊：
影响因子：
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通讯作者：
Lizhong Liu;Yang Bai;Hai Zheng;Xiongfei Fu;Chenli Liu
中科院分区：
文献类型：
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作者：
Lizhong Liu;Yang Bai;Hai Zheng;Xiongfei Fu;Chenli Liu
合成生物学是一门新兴的跨学科研究领域。通过设计和建造新的或重新设计现有的自然系统，它赋予它们在自然界中不存在的新功能。合成生物学由于其可预测性和可控性，越来越受到生物学家、物理学家和工程师的关注。合成生物学方法不仅可以广泛用于生物技术应用，而且可以用于研究复杂的生物系统来解决基本问题。在此，我们回顾了近年来遵循“构建理解”概念的研究，特别是对细胞内网络结构、细胞生理学、多细胞群体行为和生态系统的研究。
Synthetic biology is an emerging interdisciplinary research field. By designing and constructing new or re-designing the existing natural systems, it confers them novel functions, which do not exist in nature. Owing to the predictability and controllability, synthetic biology attracts more and more interest from biologists, physicists, and engineers. Synthetic biology approaches not only can be widely used for biotechnological applications but also can be used to study complex biological systems to address fundamental questions. Here, we reviewed the recent studies following the concept of "build-to-understand", particularly, the studies to understand intracellular network structure, cell physiology, the behavior of multicellular populations, and ecosystems.