Single-center long-term results of renal transplantation for IgA nephropathy
Single-center long-term results of renal transplantation for IgA nephropathy
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DOI：
10.1097/00007890-199804270-00008
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发表时间：
1998-04-27
期刊：
影响因子：
6.2
通讯作者：
Vincenti, FG
中科院分区：
文献类型：
--
作者：
Bumgardner, GL;Amend, WC;Vincenti, FG
背景。先前关于IgA肾病（IgAN）肾移植术后短期随访的报道表明，其复发率高达50%，与亲属相关的供者的复发率增加，并且很少因复发而导致移植物损失。本研究对IgAN肾移植的远期效果进行了观察。1980年6月至1994年12月，54例（61例肾移植）IgA肾病终末期肾病患者在加州大学旧金山分校接受了手术。精算患者和移植物存活率与匹配的参照组进行比较。复发性疾病的相关因素（活检证实和移植物丢失）被确定。IgA患者的患者和移植物存活率都很好（移植后5年分别为100%和75%）。与尸体肾移植相比，IgA受体活体肾移植存活率较低
Background. Previous reports with short-term follow-up after renal transplantation for IgA nephropathy (IgAN) have suggested an incidence of recurrence up to 50%, an increased recurrence with living-related donors, and the rarity of graft loss due to recurrence. In this study, the long-term results of renal transplantation for IgAN were examined.Methods. Between June 1980 and December 1994, 54 patients (61 renal transplants) with end-stage renal disease due to IgA nephropathy were performed at the University of California San Francisco. Actuarial patient and graft survival were compared with a matched reference group. Correlates of recurrent disease (biopsy confirmed and graft loss were determined.Results. Patient and graft survival for IgA patients were good (100% and 75%, respectively, at 5 years after transplant). Graft survival was lower in IgA recipients with living-related compared with cadaveric renal allografts (P