Effects of dietary fish oil on serum lipids and blood coagulation in peritoneal dialysis patients.
Effects of dietary fish oil on serum lipids and blood coagulation in peritoneal dialysis patients.
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膳食鱼油对腹膜透析患者血脂和凝血的影响。
DOI：
10.1016/s0272-6386(88)80207-5
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Albrink,MJ
中科院分区：
文献类型：
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作者：
Lempert,KD;Rogers2nd,JS;Albrink,MJ
在 11 名稳定的连续不卧床腹膜透析 (CAPD) 患者中研究了每日补充富含二十碳五烯酸的鱼油的效果。在鱼油治疗 4 周之前和之后测定血清脂质、血小板聚集研究和模板出血时间。停止补充鱼油约 20 周后，重复进行血脂研究。治疗期结束时，血清甘油三酯（平均值 ± SEM）从 297 ± 42 下降至 211 ± 29 mg/dL (P< .01)，高密度脂蛋白 (HDL) 胆固醇从 45 ± 3 下降至 41 ± 3 mg/dL (P< .05)，低密度脂蛋白 (LDL) 胆固醇从 172 ± 16 上升至 208 ± 19 毫克/分升 (P< .05)。停止补充鱼油后，甘油三酯增加至278 ± 39 mg/dL，与鱼油治疗前的值没有差异。模板出血时间（TBT）、血小板计数、血细胞比容或血小板聚集反应没有发生显着变化。临床上重要的尿毒症出血并不明显。我们的结论是，对于 CAPD 患者，鱼油补充剂有利于改善高甘油三酯血症，并且摄入后不会促进尿毒症出血。然而，甘油三酯降低对动脉粥样硬化形成可能产生的有益影响可能会被高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的伴随变化所抵消。
The effects of a daily fish oil supplement rich in eicosapentaenoic acid were studied in 11 stable continuous ambulatory peritoneal dialysis (CAPD) patients. Serum lipids, platelet aggregation studies, and template bleeding times were determined before and after 4 weeks of fish oil treatment. The lipid studies were repeated approximately 20 weeks after stopping fish oil supplement. At the end of the treatment period, serum triglycerides (mean ± SEM) decreased from 297 ± 42 to 211 ± 29 mg/dL (P< .01), high density lipoprotein (HDL) cholesterol fell from 45 ± 3 to 41 ± 3 mg/dL (P< .05), and low density lipoprotein (LDL) cholesterol increased from 172 ± 16 to 208 ± 19 mg/dL (P< .05). After discontinuing the fish oil supplement, the triglycerides increased to 278 ± 39 mg/dL, which was no different than the value before fish oil treatment. No significant changes occurred in template bleeding time (TBT), platelet count, hematocrit, or platelet aggregation response. Clinically important uremic bleeding was not apparent. We conclude that in CAPD patients a fish oil supplement favorably effects hypertriglyceridemia and can be ingested without promoting uremic bleeding. The likely beneficial impact on atherogenesis resulting from the lowering of the triglycerides may, however, be counteracted by concomitant changes in HDL- and LDL-cholesterol.