A partial nuclear genome of the Jomons who lived 3000 years ago in Fukushima, Japan.
A partial nuclear genome of the Jomons who lived 3000 years ago in Fukushima, Japan.
复制标题
DOI：
10.1038/jhg.2016.110
复制
发表时间：
2017-02
影响因子：
3.5
通讯作者：
Saitou N
中科院分区：
文献类型：
--
作者：
Kanzawa-Kiriyama H;Kryukov K;Jinam TA;Hosomichi K;Saso A;Suwa G;Ueda S;Yoneda M;Tajima A;Shinoda KI;Inoue I;Saitou N
日本列岛的绳纹时代，以绳纹陶器为特征，产生了丰富的人类骨骼遗骸。然而，绳纹人的遗传起源及其与现代人口的关系尚未澄清。我们确定了总共1.15亿个碱基对的核基因组序列，从两个绳纹个体（男性和女性）从Sanganji贝壳丘（日期3000年前）与绳纹特征的线粒体DNA单倍型组N9b，并比较这些核基因组序列与世界各地的人口。我们发现，绳纹人口谱系最好被认为是今天的东欧亚人口多样化之前，没有证据表明绳纹和其他大陆人口之间的基因流事件的分歧。这表明，三岸寺绳文人是东亚人口分散早期的后裔。我们还估计，现代日本大陆人继承了不到20%的绳纹人基因组。我们的研究结果基于对绳纹核基因组序列数据的首次分析，坚定地表明现代日本大陆是土著绳纹人和后来移民的基因混合的结果。
The Jomon period of the Japanese Archipelago, characterized by cord-marked ‘jomon' potteries, has yielded abundant human skeletal remains. However, the genetic origins of the Jomon people and their relationships with modern populations have not been clarified. We determined a total of 115 million base pair nuclear genome sequences from two Jomon individuals (male and female each) from the Sanganji Shell Mound (dated 3000 years before present) with the Jomon-characteristic mitochondrial DNA haplogroup N9b, and compared these nuclear genome sequences with those of worldwide populations. We found that the Jomon population lineage is best considered to have diverged before diversification of present-day East Eurasian populations, with no evidence of gene flow events between the Jomon and other continental populations. This suggests that the Sanganji Jomon people descended from an early phase of population dispersals in East Asia. We also estimated that the modern mainland Japanese inherited <20% of Jomon peoples' genomes. Our findings, based on the first analysis of Jomon nuclear genome sequence data, firmly demonstrate that the modern mainland Japanese resulted from genetic admixture of the indigenous Jomon people and later migrants.