High incidence and regression rates of solar keratoses in a queensland community
High incidence and regression rates of solar keratoses in a queensland community
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DOI：
10.1046/j.1523-1747.2000.00048.x
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发表时间：
2000-08-01
影响因子：
6.5
通讯作者：
Green, A
中科院分区：
文献类型：
--
作者：
Frost, C;Williams, G;Green, A
皮肤上日光性角化病的存在是基底细胞癌和鳞状细胞癌的主要危险因素之一，基底细胞癌和鳞状细胞癌构成了当今白色人群中日益严重的公共卫生问题。尽管如此，对日光性角化病的自然史知之甚少。我们在昆士兰州的纳米比亚社区随机抽样（N = 96）进行随访研究，以监测日光性角化病的发病率、消退率和复发率。在基线时，43名参与者（46%）被诊断患有至少一种日光性角化病[26名男性（55%），17名女性（37%）]，总计数为494例日光性角化病。每个人的病变分布是高度偏态的，其中11人（12%）占日光性角化病总数的65%。在12个月的随访中，诊断出614例日光性角化病（男性549例，女性65例）; 526例日光性角化病消退，53例日光性角化病复发，男性日光性角化病数量净增加45%（从354例增加到512例），女性日光性角化病数量净减少44%（从114例减少到64例）。日光性角化病的消退率普遍（74%）高于偶发（29%）。日光性角化病的患病率随着年龄的增长而增加，在基线时有日光性角化病的个体在接下来的12个月内发生日光性角化病的可能性是基线时没有日光性角化病的个体的7倍以上。这些结果表明，太阳能角化病在社会的自然历史是一个高营业额和一小部分的易感个体进行太阳能角化病在社会上的主要负担。
The presence of solar keratoses on the skin is one of the major risk factors for basal cell and squamous cell carcinomas, which constitute a growing public health problem in today's white populations. In spite of this, little is known of the natural history of solar keratoses. We conducted follow-up studies to monitor the incidence, regression, and recurrence rates of solar keratoses in a random sample (N = 96) of the Nambour community in Queensland. At baseline, 43 participants (46%) were diagnosed with at least one solar keratosis [26 men (55%), 17 women (37%)] with a total count of 494 prevalent solar keratoses. The distribution of lesions per person was highly skewed, with 11 individuals (12%) having 65% of the total number of solar keratoses. During 12 mo of follow-up, 614 incident solar keratoses were diagnosed (549 in men and 65 in women); 526 solar keratoses regressed and 53 prevalent solar keratoses recurred, giving a net 45% increase in solar keratosis numbers in men (from 354 to 512 solar keratoses) and a net 44% reduction in women (from 114 to 64). Regression rates were higher in prevalent (74%) than incident (29%) solar keratoses. Solar keratosis prevalence increased with age in both sexes, and individuals with solar keratoses at baseline were over seven times more likely to develop additional solar keratoses in the next 12 mo than those without prevalent solar keratoses at baseline. These results show that the natural history of solar keratoses in the community is one of high turnover and that a small percentage of susceptible individuals carry the major burden of solar keratoses in the community.