Different patterns of activation markers expression and CD4+T-cell responses to ex vivo stimulation in patients with clinically quiescent multiple sclerosis (MS)
Different patterns of activation markers expression and CD4+T-cell responses to ex vivo stimulation in patients with clinically quiescent multiple sclerosis (MS)
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DOI：
10.1016/j.jneuroim.2007.06.021
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发表时间：
2007-09-01
影响因子：
3.3
通讯作者：
Frydecka, I.
中科院分区：
文献类型：
--
作者：
Kosmaczewska, A.;Bilinska, M.;Frydecka, I.
与对照组相比，复发缓解型（RR）和继发进行型（SP）多发性硬化（MS）患者尽管处于长期临床缓解期，但在新鲜分离的外周血（PB）CD 4 + T细胞中，活化标志物：CD 69、CD 40 L以及膜/表面和细胞质CTLA-4（分别为mCTLA-4和cCTLA-4）的表达增加模式不同。还观察到两组MS患者对离体刺激的反应失调，伴有IFN-γ合成增加。我们的研究结果可能表明，导致每种临床形式的疾病的机制可能是异质性的。(C)2007 Elsevier B. V.保留所有权利。
Patients with relapsing-remitting (RR) and secondary progressive (SP) forms of multiple sclerosis (MS), although in long-term clinical remission, showed different patterns of increased expressions of the activation markers: CD69, CD40L, and both membrane/surface and cytoplasmic CTLA-4 (mCTLA-4 and cCTLA-4, respectively) in freshly isolated peripheral blood (PB) CD4+ T cells compared with controls. Also observed were dysregulated responses to ex vivo stimulation in both groups of MS patients accompanied by increased IFN-gamma synthesis. Our findings may suggest that the mechanisms leading to each clinical form of the disease may be heterogeneous. (C) 2007 Elsevier B.V. All rights reserved.