Avian leukosis virus subgroup J-associated myelocytoma in a hobby chicken.
Avian leukosis virus subgroup J-associated myelocytoma in a hobby chicken.
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DOI：
10.1136/vr.104626
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发表时间：
2018-01-06
期刊：
影响因子：
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通讯作者：
Welchman, David
中科院分区：
文献类型：
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作者：
Smith, Lorraine P;Petheridge, Lawrence;Welchman, David
禽白血病病毒（ALV）是与家禽肿瘤疾病相关的一类主要逆转录病毒。 20 世纪 80 年代，ALV-J 菌株被确定为英国肉种鸡和肉鸡骨髓细胞瘤的病因；然而，在消灭该病毒后，自 2000 年代初以来，商业肉鸡一直没有受到感染。一只宠物鸡于2013年被提交给动植物健康局（APHA），该鸡有呼吸鸣叫、左眼异常和明显瘫痪的病史。对该鸟的尸检显示，许多器官都有广泛的肿瘤样浸润，包括胸肌、内脏、胸骨和肋骨。对受影响组织的组织病理学检查显示，骨髓细胞瘤形成是 ALV-J 相关病变的典型特征，并且通过 PCR 检测和测序证实了该病毒。鸡群中其余五只鸡的血液样本中未检测到病毒。感染源尚未确定。这是 ALV-J 自根除以来首次在英国出现，该案例凸显了持续监测后院鸡和业余爱好者的重要性，以发现潜在的新的和重新出现的疾病威胁，例如 ALV-J，这可能对更广泛的家禽种群具有重要意义。
The avian leukosis viruses (ALVs) are a major group of retroviruses associated with neoplastic diseases in poultry. The ALV-J strain was identified as a cause of myelocytomas in broiler breeder and broiler chickens in the UK in the 1980s; however, following eradication of the virus,commercial broilers have remained free of infection since the early 2000s. A pet chicken was submitted to Animal and Plant Health Agency (APHA) in 2013 with a history of croaking respirations, abnormality of the left eye and apparent paralysis. Postmortem examination of the bird showed widespread tumour-like infiltration of many organs, including the pectoral muscles, internal organs, sternum and ribs. Histopathological examination of the affected tissues revealed myelocytoma formation typical of the lesions associated with ALV-J, and the virus was confirmed by PCR testing and sequencing. Virus was not detected in blood samples in the other five chickens remaining in the flock. The source of infection was not established. This was the first time ALV-J had been seen in the UK since its eradicationand the case highlights the importance of continued surveillance of backyard and hobby chickens to detect potential new and re-emerging disease threats, such as ALV-J, which may be of significance to the wider poultry population.