PSEUDOTYPE FORMATION BETWEEN ENVELOPED RNA AND DNA VIRUSES
PSEUDOTYPE FORMATION BETWEEN ENVELOPED RNA AND DNA VIRUSES
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DOI：
10.1038/252743a0
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发表时间：
1974-01-01
期刊：
影响因子：
64.8
通讯作者：
ROIZMAN, B
中科院分区：
文献类型：
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作者：
HUANG, AS;PALMA, EL;ROIZMAN, B
来自不同群体的包膜RNA病毒在宿主细胞质膜成熟过程中很容易相互参与表型混合。这些“假型”具有一种病毒的包膜抗原和另一种病毒的基因组，已在猿猴病毒 5 和水泡性口炎病毒 (VSV)1、禽类或鼠 RNA 肿瘤病毒和 VSV2-4、以及鸡瘟病毒和 VSV5 中得到证实。 （一个例外是辛德比斯病毒和 VSV6 之间缺乏相互作用。）我们现在在 DNA 病毒、单纯疱疹病毒 (HSV) 的包膜抗原中发现了含有 VSV RNA 基因组的病毒颗粒。基因组和不相关群体的抗原之间的这些相互作用可能是病毒发病机制和肿瘤发生机制的一部分。
ENVELOPED RNA viruses from different groups participate readily with each other in phenotypic mixing during maturation at the plasma membrane of host cells. These ‘pseudotypes’ with the envelope antigens of one virus and the genome of the other have been demonstrated for simian virus 5 and vesicular stomatitis virus (VSV)1, for avian or murine RNA tumour viruses and VSV2–4, and for fowl plague virus and VSV5. (An exception has been the lack of interaction between Sindbis virus and VSV6.) We have now found virions containing the RNA genomes of VSV in the envelope antigens of a DNA virus, herpes simplex virus (HSV). These interactions between genomes and antigens of unrelated groups may be part of a mechanism for viral pathogenesis and oncogenesis.