The definition of severe and early-onset preeclampsia. Statements from the International Society for the Study of Hypertension in Pregnancy (ISSHP)
The definition of severe and early-onset preeclampsia. Statements from the International Society for the Study of Hypertension in Pregnancy (ISSHP)
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DOI：
10.1016/j.preghy.2013.04.006
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发表时间：
2013-01-01
影响因子：
2.2
通讯作者：
Sibai, Baha M.
中科院分区：
文献类型：
--
作者：
Tranquilli, Andrea L.;Brown, Mark A.;Sibai, Baha M.
目的：文献中对重度和早发性子痫前期的定义存在差异。我们的目的是确定这些定义用于临床，并将其引入妊娠高血压疾病的分类以供出版。方法：我们向国际妊娠高血压研究学会国际委员会分发了一份问卷，重点是定义重度子痫前期的阈值和定义早发性子痫前期的妊娠，以及重度子痫前期HELLP综合征或其他临床特征的定义和纳入。所有问题都是封闭的，但所有答案都有空间进行更开放的详细评论。结果：普遍同意，如果血压为>；160 mm Hg收缩或110 mm Hg舒张压，则将先兆子痫定义为重度。对于定义严重程度的蛋白尿量，几乎没有达成一致意见。HELLP综合征被认为是包括在严重分类中的一个特征。大多数研究者认为早发性先兆子痫发生在34周之前。结论：先兆子痫的定义对于推动良好的临床实践至关重要。另一方面，分类对于临床数据和结果的国际比较是有用的。我们利用这项调查的结果来更新我们以前的分类，目的是提供有望被国际文献接受的重度和早发性子痫前期的临床研究定义。(C)2012年国际妊娠期高血压研究学会。爱思唯尔出版，版权所有。
Objective: There is discrepancy in the literature on the definitions of severe and early-onset pre-eclampsia. We aimed to determine those definitions for clinical purposes and to introduce them in the classification of the hypertensive disorders of pregnancy for publication purposes.Methods: We circulated a questionnaire to the International Committee of the International Society for the Study of Hypertension in Pregnancy focusing on the thresholds for defining severe preeclampsia and the gestation at which to define early-onset preeclampsia, and on the definition and inclusion of the HELLP syndrome or other clinical features in severe preeclampsia. The questions were closed, but all answers had space for more open detailed comments.Results: There was a general agreement to define preeclampsia as severe if blood pressure was >160 mmHg systolic or 110 mmHg diastolic. There was scarce agreement on the amount of proteinuria to define severity. The HELLP syndrome was considered a feature to include in the severe classification. Most investigators considered early-onset preeclampsia as that occurring before 34 weeks.Conclusions: A definition of pre-eclampsia is paramount for driving good clinical practice. Classifications on the other hand are useful to enable international comparisons of clinical data and outcomes. We used the results of this survey to update our previous classification for the purposes of providing clinical research definitions of severe and early onset preeclampsia that will hopefully be accepted in the international literature. (C) 2012 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.