L-carnitine alleviates alcohol-induced liver damage in rats:: Role of tumour necrosis factor-alpha
L-carnitine alleviates alcohol-induced liver damage in rats:: Role of tumour necrosis factor-alpha
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DOI：
10.1093/alcalc/agg109
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发表时间：
2003-09-01
影响因子：
2.8
通讯作者：
Lindros, K
中科院分区：
文献类型：
--
作者：
Bykov, I;Järveläinen, H;Lindros, K
目的：过量的酒精摄入诱导肝脏脂肪浸润，这已被认为是敏感的肝脏进一步损害。为了验证这一假设，L-肉毒碱，宪法亲脂化合物，长期给予大鼠乙醇的液体饮食喂养10周。结果如下：乙醇给药引起明显的脂肪变性、轻度炎症和血浆丙氨酸氨基转移酶和肿瘤坏死因子α（TNF-α）浓度升高。膳食补充L-肉碱显着降低了所有这些参数，以及肝浓度的硫代巴比妥酸反应物质，脂质过氧化产物的指标。用L-肉毒碱预处理也显著减弱了乙醇诱导的TNF-α释放的刺激。结论：这项研究为脂肪变性使肝脏对进一步损伤敏感的观点提供了直接支持，并表明TNF-α参与了这一过程。
Aims: Excessive alcohol intake induces hepatic fatty infiltration, which has been suggested to sensitize the liver to further damage. To test this hypothesis, L-carnitine, a constitutional lipotropic compound, was administered to rats chronically treated with ethanol by liquid diet feeding for 10 weeks. Results: Ethanol administration caused marked steatosis, mild inflammation and elevated plasma alanine aminotransferase and tumour necrosis factor alpha (TNF-alpha) concentrations. Dietary supplementation with L-carnitine significantly reduced all these parameters as well as the hepatic concentration of thiobarbituric acid reactive substances, an indicator of lipid peroxidation products. Pretreatment with L-carnitine also significantly blunted ethanol-induced stimulation of TNF-alpha release by isolated Kupffer cells. Conclusions: This study provides direct support for the notion that steatosis sensitizes the liver to further damage and suggests an involvement of TNF-alpha in this process.