Triggers, targets and treatments for thrombosis
Triggers, targets and treatments for thrombosis
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DOI：
10.1038/nature06797
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发表时间：
2008-02-21
期刊：
影响因子：
64.8
通讯作者：
Mackman, Nigel
中科院分区：
文献类型：
--
作者：
Mackman, Nigel
血栓形成——局部血液凝固，可发生在动脉或静脉循环中，具有重要的医学影响。急性动脉血栓形成是大多数心肌梗死（心脏病发作）和约80%中风的近端原因，它们是发达国家最常见的死亡原因。静脉血栓栓塞是心血管相关死亡的第三大原因。发生在血管壁和血液本身的致病变化导致血栓形成尚不完全清楚。了解这些过程对于开发更安全、更有效的抗血栓药物至关重要。
Thrombosis-localized clotting of the blood-can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction ( heart attack) and of about 80% of strokes, collectively the most common cause of death in the developed world. Venous thromboembolism is the third leading cause of cardiovascular-associated death. The pathogenic changes that occur in the blood vessel wall and in the blood itself resulting in thrombosis are not fully understood. Understanding these processes is crucial for developing safer and more effective antithrombotic drugs.