Increased human immunodeficiency virus loads in active methamphetamine users are explained by reduced effectiveness of antiretroviral therapy
Increased human immunodeficiency virus loads in active methamphetamine users are explained by reduced effectiveness of antiretroviral therapy
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DOI：
10.1086/379894
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发表时间：
2003-12-15
影响因子：
6.4
通讯作者：
Grant, I
中科院分区：
文献类型：
--
作者：
Ellis, RJ;Childers, ME;Grant, I
甲基苯丙胺（METH）滥用是一种常见的合并症。感染人类免疫缺陷病毒（HIV）1型的个体。在细胞培养和动物模型中，METH加速逆转录病毒复制。为了确定METH是否会增加HIV在人类中的复制，我们评估了HIV阳性METH使用者和非使用者的HIV载量。我们研究了三组：Tox（+），积极使用METH和阳性尿液毒理学结果; METH（+）Tox（-），既往METH依赖/滥用和阴性尿液毒理学结果; METH（-）Tox（-），无METH依赖/滥用和阴性尿液毒理学结果。Tox（+）受试者的血浆病毒载量显著高于METH（+）Tox（-）和METH-Tox-受试者;脑脊液病毒载量显示类似但不显著的趋势。根据使用高效抗逆转录病毒治疗（HAART）进行分层，发现仅报告接受HAART的Tox（+）受试者的病毒载量较高。相比之下，接受HAART的禁欲前METH滥用者（METH（+）Tox（-））有效抑制了病毒复制。这些数据表明，禁欲计划是有效治疗冰毒滥用人群中艾滋病毒的关键组成部分。
Abuse of methamphetamine (METH) is a frequent comorbidity. among individuals infected with human immunodeficiency virus (HIV) type 1. In cell cultures and animal models, METH accelerates retroviral replication. To determine whether METH increases HIV replication in humans, we evaluated HIV loads in HIV-positive METH users and nonusers. We studied 3 groups: Tox(+), active METH use and positive urine toxicology results; METH(+)Tox(-), previous METH dependence/abuse and negative urine toxicology results; METH(-)Tox(-), no METH dependence/abuse and negative urine toxicology results. Tox(+) subjects' plasma virus loads were significantly higher than METH(+)Tox(-) and METH-Tox- subjects'; cerebrospinal fluid virus loads showed a similar but nonsignificant trend. Stratification by use of highly active antiretroviral therapy (HAART) revealed that virus loads were higher only in those Tox(+) subjects who reported receiving HAART. In contrast, abstinent former METH abusers (METH(+)Tox(-)) receiving HAART effectively suppressed viral replication. These data suggest that abstinence programs are a key component of effective treatment of HIV in METH-abusing populations.