A content analysis of the views of genetics professionals on race, ancestry, and genetics.
A content analysis of the views of genetics professionals on race, ancestry, and genetics.
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DOI：
10.1080/23294515.2018.1544177
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发表时间：
2018-10-01
影响因子：
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通讯作者：
Bamshad, Michael J
中科院分区：
文献类型：
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作者：
Nelson, Sarah C;Yu, Joon-Ho;Bamshad, Michael J
在过去十年中，关于人类健康和疾病的遗传学研究的激增重新激发了关于种族和血统在研究和临床护理中的适当作用的辩论。在这里，我们报告了遗传学专业人员对一项调查的反应，该调查是关于他们在科学，医学和社会领域对种族，遗传学和血统的看法。通过对515名调查受访者的自由文本评论进行定性内容分析，我们确定了与种族的多重含义、种族作为遗传血统的代表的使用以及种族和血统与健康的相关性有关的关键主题。我们的研究结果表明，对于许多遗传学专业人士来说，种族是什么以及种族意味着什么的问题仍然存在专业和个人争议。展望未来，随着基因组学转化为精准医学的实践，以及学习型医疗保健系统通过综合研究提供持续的护理改进，我们主张在研究和护理环境中对种族和遗传血统进行细致入微的考虑。
Over the past decade, the proliferation of genetic studies on human health and disease has reinvigorated debates about the appropriate role of race and ancestry in research and clinical care. Here we report on the responses of genetics professionals to a survey about their views on race, genetics, and ancestry across the domains of science, medicine, and society. Through a qualitative content analysis of free-text comments from 515 survey respondents, we identified key themes pertaining to multiple meanings of race, the use of race as a proxy for genetic ancestry, and the relevance of race and ancestry to health. Our findings suggest that for many genetics professionals the questions of what race is and what race means remain both professionally and personally contentious. Looking ahead as genomics is translated into the practice of precision medicine and as learning health care systems offer continued improvements in care through integrated research, we argue for nuanced considerations of both race and genetic ancestry across research and care settings.