Hepatic hemosiderosis in non-human primates: Quantification of liver iron using different field strengths
Hepatic hemosiderosis in non-human primates: Quantification of liver iron using different field strengths
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DOI：
10.1002/mrm.1910370409
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发表时间：
1997-04-01
影响因子：
3.3
通讯作者：
Frank, JA
中科院分区：
文献类型：
--
作者：
Bulte, JWM;Miller, GF;Frank, JA
使用特发性血色病的非人灵长类动物模型，在0.05至1.5特斯拉范围内的9种不同场强下评估含铁血黄素诱导的肝脏T-2缩短。1/T-2值随场强线性增加，所有标本具有大致相同的零场截距。被称为“场依赖性T-2质子弛豫增强（PRE）”，似乎与化学测定的组织铁含量成比例，即10.8 s（-1）T（-1）（mg Fe/g湿组织）（-1）。铁含量与场依赖性T-2 PRE的相关性（r = 0.94）优于单场强下铁含量与1/T-2值之间的相关性。对于含铁量大于或等于2 mg Fe/g湿重的肝脏，双指数T，在较高场强下出现弛豫行为，其中短T-2组分（细胞内水）表现出1/T-2的线性依赖性，而长组分（细胞外/正弦水）的T-2几乎不依赖于场。浸软后的标本，所有的T-2弛豫曲线成为单指数，包括那些高铁含量在高场强，目前的数据表明，使用双场MR成像，以评估场依赖性T-2 PRE有可能具体量化（肝）组织铁存储。
Using a non-human primate model of idiopathic hemochromatosis, hemosiderin-induced T-2 shortening of the liver was assessed at nine different field strengths over a range of 0.05 to 1.5 Tesla, The 1/T-2 values increased linearly with field strength, with all specimens having approximately the same zero-field intercept, The slope of the field increase, termed ''field-dependent T-2 proton relaxation enhancement (PRE)'', appeared to be proportional to the chemically determined tissue iron content, viz. 10.8 s(-1)T(-1)(mg Fe/g wet tissue)(-1). The correlation between iron content and field-dependent T-2 PRE (r = 0.94) was better than the correlation between iron content and 1/T-2 values obtained at single field strengths, For livers containing greater than or equal to 2 mg Fe/g wet weight, biexponential T,relaxation behavior emerged at higher field strengths, with the short T-2 component (intracellular water) exhibiting a linear dependence of 1/T-2 on field, while T-2 of the long component (extracellular/sinusoidal water) was nearly field-independent. After maceration of the specimens, all T-2 relaxation curves became monoexponential, including those for high iron content at high field strengths, The present data suggest that the use of double-field MR imaging to assess the field-dependent T-2 PRE has potential for specific quantification of (liver) tissue iron stores.