TESTING THE CONSTANT-RATE NEUTRAL ALLELE MODEL WITH PROTEIN-SEQUENCE DATA
TESTING THE CONSTANT-RATE NEUTRAL ALLELE MODEL WITH PROTEIN-SEQUENCE DATA
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DOI：
10.1111/j.1558-5646.1983.tb05528.x
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发表时间：
1983-01-01
期刊：
影响因子：
3.3
通讯作者：
HUDSON, RR
中科院分区：
文献类型：
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作者：
HUDSON, RR
提出了一种测试蛋白质进化的恒定速率中性等位基因模型的方法，并将其应用于大数据集。该方法使用 Langley 和 Fitch (1973, 1974) 以及 Fitch 和 Langley (1976) 使用的相同统计量 χ2LF。本研究中通过蒙特卡罗模拟表征的 χ2LF 分布取决于参数 θ (=4Nu)。确定了解释观察到的 χ2LF 值所需的 θ 值，发现该值与在人类血红蛋白位点观察到的低杂合性水平不相容。结论是，恒定利率中性模型的可能性极小。需要考虑其他中性模型和涉及自然选择的模型。
A method of testing the constant-rate neutral allele model of protein evolution is presented and applied to a large data set. The method uses the same statistic, χ2LF, used by Langley and Fitch (1973, 1974) and Fitch and Langley (1976). The distribution of χ2LF, characterized in this study with Monte Carlo simulations, depends on the parameter θ (=4Nu). The values of θ required to explain the observed value of χ2LFare determined and found to be incompatible with the low levels of heterozygosity observed at the hemoglobin loci in humans. It is concluded that the constant-rate neutral model is highly improbable. Other neutral models and models involving natural selection need to be considered.