Familial correlates of central serotonin function in children with disruptive behavior disorders
Familial correlates of central serotonin function in children with disruptive behavior disorders
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DOI：
10.1016/s0165-1781(03)00136-7
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发表时间：
2003-08-01
影响因子：
11.3
通讯作者：
Newcorn, JH
中科院分区：
文献类型：
--
作者：
Halperin, JM;Schulz, KP;Newcorn, JH
以往的研究结果表明，儿童期的攻击，父母的攻击历史和中枢5-羟色胺（5-HT）功能之间的关系。本研究通过检查儿童期攻击性和中枢5-HT功能对患有破坏性行为障碍的青春期前儿童的一级和二级亲属的精神病理学发生率的影响，扩展了这些发现。获得了58名攻击性和44名非攻击性临床转诊儿童的精神病理学家族史，这些儿童根据中枢5-HT功能进一步细分。通过测量催乳素对1 mg/kg口服剂量的d，l-芬氟拉明的反应来评估中枢5-HT功能。与非攻击性儿童和高催乳素反应的攻击性儿童相比，对芬氟拉明具有低催乳素反应的攻击性儿童具有攻击性和反社会特征的一级和二级亲属的发生率显著更高。亲属出现认知障碍或注意力不集中和多动症状的频率没有组间差异。这些数据表明，有家庭和非家庭形式的攻击儿童，只有家庭类型与降低5-HT功能。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
Previous findings suggest a relationship between childhood aggression, parental history of aggression and central serotonin (5-HT) function. The present study extended these findings by examining the impact of childhood aggression and central 5-HT function on the incidence of psychopathology in first- and second-degree relatives of pre-pubertal children with disruptive behavior disorders. Family history of psychopathology was obtained for 58 aggressive and 44 non-aggressive clinically referred children who were further sub-divided based on central 5-HT function. Central 5-HT function was assessed by measuring the prolactin response to a 1 mg/kg oral dose of d,l-fenfluramine. Aggressive children with low-prolactin responses to fenfluramine had a significantly greater incidence of first- and second-degree relatives with aggressive and antisocial characteristics compared to both non-aggressive children and aggressive children with high-prolactin responses. No group differences were found in the frequency of relatives with symptoms of cognitive impairment or inattention and hyperactivity. These data suggest that there are both familial and non-familial forms of aggression in children, and that only the familial type is associated with reduced 5-HT function. (C) 2003 Elsevier Ireland Ltd. All rights reserved.