No trace of phase: Corticomotor excitability is not tuned by phase of pericentral mu-rhythm
No trace of phase: Corticomotor excitability is not tuned by phase of pericentral mu-rhythm
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DOI：
10.1016/j.brs.2019.05.005
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发表时间：
2019-09-01
影响因子：
7.7
通讯作者：
Siebner, Hartwig Roman
中科院分区：
文献类型：
--
作者：
Madsen, Kristoffer Hougaard;Karabanov, Anke Ninija;Siebner, Hartwig Roman
背景资料：经颅磁刺激（TMS）在运动手区域（M1-HAND）诱发的运动电位显示出显著的试验间变异性。中心周围μ节律振荡可能导致试验间变异性。基于实时脑电图（EEG）的针对μ活动的最新研究报告了在具有强中央周围μ活动的预选组中μ功率和μ相位对运动诱发电位（MEP）振幅的影响。根据非预选个体的事后试验分类确定μ功率或μ相位的其他研究在很大程度上是负面的。目的：为了重新评估皮质脊髓活动是否受μ节律调节，我们在14名非预选健康年轻参与者的内在表达的中央周围μ节律的相位条件下，将单脉冲TMS应用于M1-HAND。方法：在μ相位的0、90、180和270度处给予TMS。基于在分析MEP平均振幅时没有μ相位或μ功率的影响，我们还计算了一个线性混合效应模型，该模型包括μ相位，μ功率，刺激间间隔（ISI）作为固定效应，将主题因素作为随机效应。MEP振幅线性缩放与较低的μ功率或较长的ISI，但这些调制效果是非常小的相对于试验间MEP variability.Conclusion：我们的主要是负面的结果是在协议与以前的离线TMS-EEG研究和点ISI的可能影响。未来的研究需要阐明在何种情况下人类M1-HAND对TMS的反应依赖于与μ功率和μ相位的同步性。(C)2019年，任作家。爱思唯尔公司出版
Background: The motor potentials evoked by transcranial magnetic stimulation (TMS) over the motor hand area (M1-HAND) show substantial inter-trial variability. Pericentral mu-rhythm oscillations, might contribute to inter-trial variability. Recent studies targeting mu-activity based on real-time electroencephalography (EEG) reported an influence of mu-power and mu-phase on the amplitude of motor evoked potentials (MEPs) in a preselected group with strong pericentral mu-activity. Other studies that determined mu-power or mu-phase based on post-hoc trial sorting according in non-preselected individuals were largely negative.Objectives: To reassess if cortico-spinal activity is modulated by the mu-rhythm, we applied single-pulse TMS to the M1-HAND conditional on the phase of the intrinsically expressed pericentral mu-rhythm in 14 non-preselected healthy young participants.Methods: TMS was given at 0, 90, 180, and 270 degrees of the mu-phase. Based on the absence of effects of mu-phase or mu-power when analyzing the mean MEP amplitudes, we also computed a linear mixed effects model, which included mu-phase, mu-power, inter-stimulus interval (ISIs) as fixed effects, treating the subject factor as a random effect.Results: Mixed model analysis revealed a significant effect of mu-power and ISI, but no effect of mu-phase and no interactions. MEP amplitude scaled linearly with lower mu-power or longer ISIs, but these modulatory effects were very small relative to inter-trial MEP variability.Conclusion: Our largely negative results are in agreement with previous offline TMS-EEG studies and point to a possible influence of ISI. Future research needs to clarify under which circumstances the responsiveness of human the M1-HAND to TMS depends on the synchronicity with mu-power and mu-phase. (C) 2019 The Authors. Published by Elsevier Inc.