Medial Prefrontal-Hippocampal Connectivity and Motor Memory Consolidation in Depression and Schizophrenia
Medial Prefrontal-Hippocampal Connectivity and Motor Memory Consolidation in Depression and Schizophrenia
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DOI：
10.1016/j.biopsych.2014.06.004
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发表时间：
2015-01-15
影响因子：
10.6
通讯作者：
Goya-Maldonado, Roberto
中科院分区：
文献类型：
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作者：
Genzel, Lisa;Dresler, Martin;Goya-Maldonado, Roberto
背景：抑郁症和精神分裂症患者的夜间记忆巩固都受到干扰，这为研究睡眠相关巩固的机制以及区分疾病特有的过程和他们的病理生理学中的共同因素创造了理想的环境。方法：我们研究了抑郁症和精神分裂症患者以及健康对照受试者(n=16)，采用功能性磁共振成像和多导睡眠图的运动记忆巩固方案。结果：在与任务期间海马-前额皮质功能连接程度相关的连续手指敲击任务中，两组患者均被确定为共同的缺陷，夜间改善明显较少。在对照组和精神分裂症患者中，观察到与任务相关的一夜之间基底神经节的激活减少；相反，抑郁症患者的基底节激活增加。在任务中，与对照组相比，精神分裂症患者额外招募了邻近的皮质区域，这些区域显示出一夜之间功能磁共振成像激活的减少，并与疾病的严重程度有关。有效的连通性分析显示，海马体在功能上与运动任务网络相连，而小脑在一夜之间就脱离了这个网络。结论：虽然两组患者在与海马-前额叶皮质连通性相关的巩固方面表现出相似的缺陷，但其他更具疾病病理学特异性的活动模式不同。
BACKGROUND: Overnight memory consolidation is disturbed in both depression and schizophrenia, creating an ideal situation to investigate the mechanisms underlying sleep-related consolidation and to distinguish disease-specific processes from common elements in their pathophysiology.METHODS: We investigated patients with depression and schizophrenia, as well as healthy control subjects (each n = 16), under a motor memory consolidation protocol with functional magnetic resonance imaging and polysomnography.RESULTS: In a sequential finger-tapping task associated with the degree of hippocampal-prefrontal cortex functional connectivity during the task, significantly less overnight improvement was identified as a common deficit in both patient groups. A task-related overnight decrease in activation of the basal ganglia was observed in control subjects and schizophrenia patients; in contrast, patients with depression showed an increase. During the task, schizophrenia patients, in comparison with control subjects, additionally recruited adjacent cortical areas, which showed a decrease in functional magnetic resonance imaging activation overnight and were related to disease severity. Effective connectivity analyses revealed that the hippocampus was functionally connected to the motor task network, and the cerebellum decoupled from this network overnight.CONCLUSIONS: While both patient groups showed similar deficits in consolidation associated with hippocampal-prefrontal cortex connectivity, other activity patterns more specific for disease pathology differed.