"Focused introspection" during naturally increased diuresis: Description and repeatability of a method to study bladder sensation non-invasively
"Focused introspection" during naturally increased diuresis: Description and repeatability of a method to study bladder sensation non-invasively
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DOI：
10.1002/nau.22440
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发表时间：
2014-06-01
影响因子：
2
通讯作者：
Gillespie, James I.
中科院分区：
文献类型：
--
作者：
De Wachter, Stefan G. G.;Heeringa, Rhea;Gillespie, James I.
目的介绍一种无创性研究膀胱充盈感发生发展的方法，并评价其可重复性。方法18名受试者在运动前1h饮水1,000ml，运动中每10min饮水200ml。方案1：为了评估利尿率，要求7名参与者每15分钟排尿一次，并测量排尿量。方案2：11名志愿者在规则的时间点上对膀胱感觉进行分级，在空图上，时间在X轴上，感觉强度在Y轴上。方案在绝对需要排尿（最大强度）时结束，并测量排尿量。该方案进行了三次，间隔10天。结果方案1：利尿率在治疗期间没有差异，在研究时间段内也没有变化（P = 0.2）。方案2：对于个体而言，两次治疗之间的利尿率没有差异。所有患者的曲线均显示膀胱强度持续增加。在7名参与者中，曲线是凸形的，在其他4名参与者中，曲线是S形的。对于每个人的模式是恒定的，在三个会议。结论严格的水负荷方案可诱导持续性利尿。这允许个体绘制具有特定形状的内省膀胱感觉曲线，其可以用作非侵入性地研究膀胱感觉的发展的方法。Neurorol。Urodynam。33：502 - 506，2014. (c)2013 Wiley Periodicals，Inc.
Objective To present and describe a non-invasive method to study the origin and development of bladder filling sensation and to evaluate the repeatability of the method. Method Eighteen volunteers participated in the study and were given a water loading protocol consisting of 1,000ml water intake 1hr before the session and 200ml every 10min during the session. Protocol 1: To evaluate diuresis rate, seven participants were asked to void every 15min and the voided volume was measured. Protocol 2: Eleven volunteers graded bladder sensation on regular time points, on an empty graph with time on the X-axis and intensity of sensation on the Y-axis. The protocol ended at absolute need to void (maximal intensity) and voided volumes were measured. This protocol was conducted three times with a 10 days interval. Results Protocol 1: The diuresis rate was not different during the sessions and showed no variation over the studied time period (P=0.2). Protocol 2: For an individual, the diuresis rate was not different between the sessions. The curves in all patients showed a continuously increasing bladder intensity. In seven participants the curve was convex, in the other four, the curve was sigmoidal. For each individual the pattern was constant during the three sessions. Conclusion A strict water loading protocol induces a constant diuresis. This allows individuals to draw an introspection bladder sensation curve with a specific shape, which can be used as a method to study the development of bladder sensation non-invasively. Neurourol. Urodynam. 33:502-506, 2014. (c) 2013 Wiley Periodicals, Inc.