Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus
Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus
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DOI：
10.1007/s10875-007-9104-0
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发表时间：
2007-09-01
影响因子：
9.1
通讯作者：
Suh, Chang-Hee
中科院分区：
文献类型：
--
作者：
Chun, Hye-Young;Chung, Jae-Wook;Suh, Chang-Hee
人们对识别与系统性红斑狼疮 (SLE) 疾病活动密切相关的生物标志物非常感兴趣，但很少有生物标志物得到验证。细胞因子在SLE的发病机制中发挥着重要作用。因此，我们评估了细胞因子的水平及其与疾病活动的可能关联。在本研究中，我们发现与正常对照相比，SLE 患者的 IL-6、IL-10、IL-12 和 IFN-γ 水平较高，但 IL-2 水平较低。活动性 SLE 患者的血清 IL-6 水平显着升高，并与 SLE 活动指数 (SLEDAI)、红细胞沉降率 (ESR) 和 C 反应蛋白 (CRP) 相关。活动性 SLE 患者的血清 IL-10 水平也显着升高，并与 SLEDAI 和抗双链 DNA (dsDNA) 滴度呈正相关，与 C3、C4 和淋巴细胞计数呈负相关。合并肾炎的 SLE 患者与未合并肾炎的 SLE 患者细胞因子水平没有显着差异。这些数据表明 IL-6 和 IL-10 可能是 SLE 疾病活动性的有用生物标志物。
There is a great deal of interest in the identification of biomarkers that are closely associated with disease activity in systemic lupus erythematosus (SLE), but few biomarkers have been validated. Cytokines play an important role in the pathogenesis of SLE. Therefore, we evaluated the levels of cytokines and their possible association with disease activity. In the present study, we found that the SLE patients had higher IL-6, IL-10, IL-12, and IFN-gamma levels, but lower IL-2, than normal controls. Serum IL-6 level was significantly elevated in active SLE patients and correlated with the SLE activity index (SLEDAI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Serum IL-10 level was also significantly elevated in active SLE patients and revealed positive correlation with SLEDAI and anti-double-stranded DNA (dsDNA) titer and negative correlation with C3, C4, and lymphocyte counts. No significant differences in the levels of cytokines were observed between SLE patients with nephritis and those without nephritis. These data suggest that IL-6 and IL-10 may be a useful biomarker for disease activity in SLE.