CD4(+) T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions.
CD4(+) T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions.
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非传染性人类免疫缺陷病毒 1 型病毒颗粒不会诱导离体人淋巴组织中 CD4( ) T 淋巴细胞的耗竭。
DOI：
10.1128/jvi.72.11.9345-9347.1998
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发表时间：
1998
影响因子：
5.4
通讯作者：
Margolis,LB
中科院分区：
文献类型：
--
作者：
Sylwester,AW;Grivel,JC;Fitzgerald,W;Rossio,JL;Lifson,JD;Margolis,LB
我们测试了传染性人类免疫缺陷病毒 1 型 (HIV-1)、非传染性但构象真实的灭活完整 HIV-1 病毒粒子和纯化的 gp120 体外诱导人淋巴组织中 CD4+T 细胞耗竭的能力。传染性CXCR4倾向性HIV-1，但不匹配的灭活病毒颗粒或gp120，介导CD4+T细胞耗竭，与需要有效感染的机制一致。
We tested infectious human immunodeficiency virus type 1 (HIV-1), noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4+T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120, mediated CD4+T-cell depletion, consistent with mechanisms requiring productive infection.