EMBRYOS OF HOMARUS-AMERICANUS ARE PROTECTED BY EPIBIOTIC BACTERIA
EMBRYOS OF HOMARUS-AMERICANUS ARE PROTECTED BY EPIBIOTIC BACTERIA
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DOI：
10.2307/1542184
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发表时间：
1992-02-01
影响因子：
1.6
通讯作者：
FENICAL, W
中科院分区：
文献类型：
--
作者：
GILTURNES, MS;FENICAL, W
美国龙虾Homarus americanus的胚胎对许多甲壳类动物的病原体--卡氏拉格尼迪姆真菌--的感染具有显著的抵抗力。健康龙虾胚胎的表面几乎完全被一种单一的革兰氏阴性细菌覆盖，这种细菌以密集的马赛克模式生长。在培养中，这种细菌在体外产生一种化合物，在10微克/毫升的浓度下完全抑制病原真菌的生长。大规模发酵、提取和随后的层析纯化导致抗真菌物质被鉴定为4-羟基苯乙醇(酪醇)，这是一种已知由陆地真菌产生的抗菌物质。
Embryos of the American lobster, Homarus americanus, are remarkably resistant to infection by the fungus Lagenidium callinectes, a pathogen of many crustaceans. The surfaces of healthy lobster embryos are covered almost exclusively by a single, Gram-negative bacterium, which grows in a dense mosaic pattern. In culture, this bacterium produces a compound that completely inhibits the growth of the pathogenic fungus in vitro at 10 mcg/ml. Large-scale fermentation, extraction, and subsequent chromatographic purification led to the identification of the antifungal substance as 4-hydroxyphenethyl alcohol (tyrosol), an antibiotic substance known to be produced by terrestrial fungi.