Application of an electronic nose system for evaluation of unpleasant odor in coated tablets.
Application of an electronic nose system for evaluation of unpleasant odor in coated tablets.
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应用电子鼻系统评价包衣片剂的不良气味。
DOI：
10.1016/j.ejpb.2004.08.008
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
T. Kashihara
中科院分区：
文献类型：
--
作者：
S. Ohmori;Y. Ohno;T. Makino;T. Kashihara
本研究的目的是应用电子鼻系统来评价含有l-半胱氨酸（一种令人不快的气味药物）的片剂中的令人不快的气味，并通过电子鼻系统和感官评价来证明我们新开发的薄层无糖包衣片剂的气味掩蔽能力。在电子鼻系统评价中，我们展示了使用空气作为参考指标的不愉快气味的定性评价和使用空气与样品之间的距离的不愉快气味的定量评价。电子鼻系统的评价与志愿者的感官评价呈正相关。我们建议，电子鼻系统的评价是适当的替代或支持方法的感官评价志愿者。作为电子鼻系统和感官评价的结果，我们证明了薄层无糖包衣片由于包衣层致密而具有与糖衣片相当的令人不快的气味的优异掩蔽能力。
The purpose of this study was to apply an electronic nose system for evaluation of unpleasant odor in tablets containing l-cysteine, an unpleasant odor drug, and demonstrate the odor masking ability of thin-layer sugarless coated tablets, which we have newly developed, by both electronic nose system and sensory evaluations. We demonstrated the qualitative evaluation of the unpleasant odor using air as a reference indicator and the quantitative evaluation of the unpleasant odor using the distances between air and samples in the electronic nose system evaluation. The electronic nose system evaluation was positively and well-correlated with the sensory evaluation by volunteers. We suggest that the electronic nose system evaluation is appropriate as an alternative or a support method for sensory evaluation by volunteers. As the results of both electronic nose system and sensory evaluations, we demonstrated that the thin-layer sugarless coated tablets have excellent masking ability of the unpleasant odor, equivalent to that of sugar-coated tablets due to the dense coating layers.