Effects of Acute Progesterone Administration Upon Responses to Acute Psychosocial Stress in Men
Effects of Acute Progesterone Administration Upon Responses to Acute Psychosocial Stress in Men
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DOI：
10.1037/a0018060
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发表时间：
2010-02-01
影响因子：
2.3
通讯作者：
de Wit, Harriet
中科院分区：
文献类型：
--
作者：
Childs, Emma;Van Dam, Nicholas T.;de Wit, Harriet
动物研究表明，神经活性类固醇，特别是黄体酮及其代谢物，具有缓解压力的作用。然而，很少有研究探讨这些对人类的影响。在这项研究中，我们调查了急性黄体酮给药对特里尔社会压力测试（TSST）反应的影响。健康男性在肌肉注射 0、50 或 100 mg 黄体酮后 3.5 小时参加 TSST（N = 16、14 和 14）。我们测量了三组的心血管（心率、血压）、激素（血浆促肾上腺皮质激素、皮质醇和去甲肾上腺素）和主观（例如焦虑、觉醒）对压力的反应。在 TSST 之前，注射黄体酮会增加血浆水平，但不会改变生理或主观状态。压力在接受安慰剂治疗的个体中产生了预期的生理和主观影响。黄体酮 50 毫克可减弱血浆皮质醇的峰值增加，并减少压力后负面情绪和警觉性的变化，但会增加血浆去甲肾上腺素和收缩压。 100 毫克黄体酮还可以减弱压力引起的警觉性和唤醒度的增加，但会增强压力引起的舒张压的增加。因此，黄体酮抑制了压力的一些心理影响，但对生理压力反应产生了不一致的影响。
Animal studies suggest that neuroactive steroids, in particular progesterone and its metabolites, have stress-dampening effects. However, few studies have explored these effects in humans. In this study, we investigated the effects of acute progesterone administration on responses to the Trier Social Stress Test (TSST). Healthy men participated in the TSST 3.5 hrs after intramuscular injection of 0, 50, or 100 mg progesterone (N = 16, 14, and 14). We measured cardiovascular (heart rate, blood pressure), hormonal (plasma adrenocorticotrophic hormone, cortisol, and noradrenaline), and subjective (e.g., anxiety, arousal) responses to stress in the three groups. Before the TSST, progesterone injections increased plasma levels without altering physiological or subjective states. Stress produced its expected physiological and subjective effects among placebo-treated individuals. Progesterone 50 mg attenuated peak increases in plasma cortisol and reduced changes in negative mood and alertness after stress, yet it increased plasma noradrenaline and systolic blood pressure. Progesterone 100 mg also attenuated stress-induced increases in alertness and arousal, yet it potentiated stress-induced increases in diastolic pressure. Thus, progesterone dampened some of the psychological effects of stress but produced inconsistent effects on physiological stress responses.