Evaluation of a synthetic C34 trimer of HIV-1 gp41 as AIDS vaccines
Evaluation of a synthetic C34 trimer of HIV-1 gp41 as AIDS vaccines
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DOI：
10.1016/j.bmc.2012.03.050
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发表时间：
2012-05-15
影响因子：
3.5
通讯作者：
Tamamura, Hirokazu
中科院分区：
文献类型：
--
作者：
Hashimoto, Chie;Nomura, Wataru;Tamamura, Hirokazu
已经评价了形成靶向HIV-1的膜融合机制的C34三聚体结构的人工抗原作为HIV疫苗。C34三聚体分子是我们以前设计和合成的，使用一种新的模板与C3-对称接头。通过免疫C34三聚体形式抗原产生的抗血清显示出对C34三聚体的结合亲和力比对C34单体高23倍，并且显示出显著的中和活性。本研究结果表明，有效的策略设计的HIV疫苗和抗HIV药物的基础上天然结构模拟蛋白质靶向动态超分子机制在HIV融合。(C)2012爱思唯尔有限公司保留所有权利。
An artificial antigen forming the C34 trimeric structure targeting membrane-fusion mechanism of HIV-1 has been evaluated as an HIV vaccine. The C34 trimeric molecule was previously designed and synthesized using a novel template with C3-symmetric linkers by us. The antiserum produced by immunization of the C34 trimeric form antigen showed 23-fold higher binding affinity for the C34 trimer than for the C34 monomer and showed significant neutralizing activity. The present results suggest effective strategies of the design of HIV vaccines and anti-HIV agents based on the native structure mimic of proteins targeting dynamic supramolecular mechanisms in HIV fusion. (C) 2012 Elsevier Ltd. All rights reserved.