COLLAGEN TURNOVER AND ITS REGULATION IN THE NORMAL AND HYPERTROPHYING HEART
COLLAGEN TURNOVER AND ITS REGULATION IN THE NORMAL AND HYPERTROPHYING HEART
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DOI：
10.1093/eurheartj/16.suppl_c.38
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发表时间：
1995-05-01
影响因子：
39.3
通讯作者：
LAURENT, GJ
中科院分区：
文献类型：
--
作者：
BISHOP, JE;LAURENT, GJ
目前已鉴定出18种不同的胶原蛋白类型，其中至少5种存在于心脏的细胞外基质中。间质胶原，I型和III型是最丰富的组分。由于它们的拉伸强度和在网络中的排列，围绕和互连肌细胞和毛细血管，这些胶原蛋白在整个心肌中传递力，在心动周期期间维持心脏结构，并有助于心肌的粘弹性。早期应用同位素技术评估周转表明，心脏胶原蛋白，与细胞质蛋白质相比，几乎是惰性的。后来开发出更精确的方法来测量其合成和降解速率，结果表明胶原蛋白的周转非常迅速，心脏细胞在整个生命过程中都会合成和降解胶原蛋白。因此，合成和降解之间平衡的变化可能导致胶原网络组成的变化，这可能对顺应性产生显著影响，从而导致心脏功能的变化。目前的研究集中在机械力和生长因子在胶原代谢调节中的作用。了解参与控制胶原代谢的调节机制是开发可逆转或预防心血管疾病中过量胶原沉积的药物的基础。
Eighteen different collagen types have now been identified, at least five of which are found in the extracellular matrix of the heart. The interstitial collagens, types I and III are the most abundant components. Due to their tensile strength and arrangement in a network, surrounding and inter-connecting myocytes and capillaries, these collagens transmit forces throughout the myocardium, maintain cardiac structure during the cardiac cycle and contribute to the visco-elastic properties of the myocardium. Early application of isotopic techniques to assess turnover suggested that heart collagen, in contrast to cytoplasmic proteins was virtually inert. The later development of more accurate methods for measuring its synthesis and degradation rates revealed that collagen turnover was quite rapid and that heart cells synthesize and degrade collagens throughout life. Thus, changes in the balance between synthesis and degradation may lead to changes in the composition of the collagen network, which may have marked effects on compliance resulting in changes in heart function. Current research is focused on the role of mechanical forces and growth factors in the regulation of collagen metabolism. An understanding of the regulatory mechanisms involved in controlling collagen metabolism is fundamental to the development of agents that may reverse or prevent excess collagen deposition in cardiovascular diseases.