Functional cognitive and cortical abnormalities in chronic and first-admission schizophrenia
Functional cognitive and cortical abnormalities in chronic and first-admission schizophrenia
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DOI：
10.1016/j.schres.2014.05.012
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发表时间：
2014-08-01
影响因子：
4.5
通讯作者：
Rockstroh, Brigitte S.
中科院分区：
文献类型：
--
作者：
Carolus, Almut M.;Schubring, David;Rockstroh, Brigitte S.
最近，诱发和诱导的事件相关神经振荡被认为是支持高阶认知的关键机制。认知衰退和异常电磁感觉门控可靠地区分精神分裂症（SZ）患者和健康个体，在慢性（TIA）和首次入院（FA）患者中得到证实。尚未确定的是是否改变事件相关的调制振荡活动表现在SZ的早期阶段，从而反映，也许体现了精神病理学的发展，并提供了一个机制的门控缺陷。本研究比较了行为和功能的大脑措施，在大脑皮层和FA样本。在符合ICD-10精神分裂症诊断标准的35名患者和31名FA患者以及28名健康对照受试者（HC）中评估了成对点击任务期间的认知测试性能（MATRICS联盟认知电池，MCCB），神经磁事件相关场（M50门控比）和振荡动力学（诱发和诱导的8-12 Hz α调制）。两个患者组均显示出较差的认知能力、较高的M50比率（较差的感觉门控）和较少的α活性诱导调节。在HC中，双侧后部区域的诱导α功率降低与M50比值有关，而在SZ中，双侧后部区域的诱导α功率降低与M50比值有关，而在HC中，双侧前部区域的诱导α功率降低与M50比值有关，而在SZ中，双侧后部区域的诱导α功率降低与M50比值有关，而在HC中，双侧前部区域的诱导α功率降低与M50比值无关。结果表明，振荡动力学在疾病的早期阶段，这可能有助于信息采样不足，记忆更新和更高的认知功能中断。(C)2014爱思唯尔有限公司版权所有。
Evoked and induced event-related neural oscillations have recently been proposed as a key mechanism supporting higher-order cognition. Cognitive decay and abnormal electromagnetic sensory gating reliably distinguish schizophrenia (SZ) patients and healthy individuals, demonstrated in chronic (CHR) and first-admission (FA) patients. Not yet determined is whether altered event-related modulation of oscillatory activity is manifested at early stages of SZ, thus reflects and perhaps embodies the development of psychopathology, and provides a mechanism for the gating deficit. The present study compared behavioral and functional brain measures in CHR and FA samples. Cognitive test performance (MATRICS Consortium Cognitive Battery, MCCB), neuromagnetic event-related fields (M50 gating ratio), and oscillatory dynamics (evoked and induced modulation of 8-12 Hz alpha) during a paired-click task were assessed in 35 CHR and 31 FA patients meeting the criteria for ICD-10 diagnoses of schizophrenia as well as 28 healthy comparison subjects (HC). Both patient groups displayed poorer cognitive performance, higher M50 ratio (poorer sensory gating), and less induced modulation of alpha activity than did HC. Induced alpha power decrease in bilateral posterior regions varied with M50 ratio in HC but not SZ, whereas orbitofrontal alpha power decrease was related to M50 ratio in SZ but not HC. Results suggest disruption of oscillatory dynamics at early stages of illness, which may contribute to deficient information sampling, memory updating, and higher cognitive functioning. (C) 2014 Elsevier B.V. All rights reserved.