Revised Structures of Epohelmins A and B Isolated as Lanosterol Synthase Inhibitors from a Fungal Strain FKI-0929
Revised Structures of Epohelmins A and B Isolated as Lanosterol Synthase Inhibitors from a Fungal Strain FKI-0929
复制标题
DOI：
10.1038/ja.2005.82
复制
发表时间：
2005-09
期刊：
影响因子：
--
通讯作者：
M. Shibuya;B. Snider;Y. Sakano;H. Tomoda;S. Ōmura;Y. Ebizuka
中科院分区：
文献类型：
--
作者：
M. Shibuya;B. Snider;Y. Sakano;H. Tomoda;S. Ōmura;Y. Ebizuka
从真菌菌株FKI-0929中分离得到的毛甾醇合成酶抑制剂epohelmins A和B的结构分别为1α-羟基-3α-（4 ' -oxoundec-(5 ' E)-烯基）-吡咯利齐啶和1β-羟基-3α-（4 ' -oxoundec-(5 ' E)-烯基）-吡咯利齐啶。
The structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929 were revised to be 1α-hydroxy-3α-(4′-oxoundec-(5′ E)-enyl)-pyrrolizidine and 1β-hydroxy-3α-(4′-oxoundec-(5′ E)-enyl)-pyrrolizidine, respectively, by comparison with spectral data of synthetic compounds.