DEVELOPMENT OF PLACE NAVIGATION IN RATS FROM WEANING TO PUBERTY
DEVELOPMENT OF PLACE NAVIGATION IN RATS FROM WEANING TO PUBERTY
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DOI：
10.1016/s0163-1047(85)91510-9
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发表时间：
1985-01-01
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影响因子：
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通讯作者：
SCHENK, F
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文献类型：
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作者：
SCHENK, F
在一池不透明的水中游泳后，幼小的蒙面老鼠被训练逃到一个隐藏的平台上。对第1天的受试者21、28、35、42天和进行28次连续5天的训练。其中一半的大鼠被要求仅根据外部房间提示来定位平台(仅限于放置条件)，另一半的大鼠通过在平台上存在可见的提示来帮助定位(提示+放置条件)。在21天和28天组中观察到了位置导航的缺陷。它们表现出缓慢的逃逸，并且比年长的老鼠更经常走迂回的路线。这一缺陷与在28次试训(试探试验)结束时，受试者在没有站台的情况下被允许游泳30 S时，对训练位置的空间偏向较差有关。35d组在两种训练条件下都表现出成人样的学习能力，但在近端线索存在的情况下进行训练后，在探测试验中没有表现出寻找行为。在探头实验中，无论训练条件如何，只有40日龄以上的大鼠表现出典型的成体行为，如从任一出发姿势直接游向平台，在缺少平台的S位置周围进行局部搜索。大鼠负责位置学习的中枢神经系统结构从32d左右开始发挥作用，但在6wk之前未能触发线索训练后的搜索行为。
Young hooded rats were trained to escape onto a hidden platform after swimming in a pool of opaque water. Subjects 21, 28, 35, 42 and 64 days of age on the 1st training day were given 28 trials on 5 consecutive days. Half of the rats were required to localize the platform in relation to external room cues only (place only condition) and the other half were helped by the presence of a visible cue on the platform (cue + place condition). A deficiency in place navigation was observed in the 21- and 28-day groups. They showed slow escape and took circuitous routes more often than older rats. This deficiency was related to a poor spatial bias toward the training position when the subjects were allowed to swim for 30 s in the absence of the platform, at the end of the 28-trial training period (probe trial). The 35-day group showed adult-like learning ability in both training conditions, but failed to show searching behavior during the probe trial after having been trained in the presence of the proximal cue. Only rats older than 40 days showed typical adult behavior such as swimming directly toward the platform from any starting position and localized searching around the absent platform''s position during the probe trial, no matter what the training conditions were. CNS structures responsible for place learning in the rat are functional from around 32 days of age, but fail to trigger searching behavior following cued training before the 6th wk.