Protective effects of photobiomodulation against resistance exercise-induced muscle damage and inflammation in rats
Protective effects of photobiomodulation against resistance exercise-induced muscle damage and inflammation in rats
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DOI：
10.1080/02640414.2018.1457419
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发表时间：
2018-01-01
影响因子：
3.4
通讯作者：
Serra, Andrey Jorge
中科院分区：
文献类型：
--
作者：
de Oliveira, Helenita Antonia;Antonio, Ednei Luiz;Serra, Andrey Jorge
我们研究了低强度激光治疗（LLLT）之前或之后的阻力运动是否可以减轻肌肉损伤和炎症。将雌性Wistar大鼠分配至非LLLT或LLLT组。使用830-nm DMC激光光子III以2 J、4J和8 J剂量照射它们的后腿。在（4J）抗阻运动之前或之后进行辐照。阻力训练包括四个最大负荷攀登。对照组（非LLLT，225 +/-10 g）、2 J组（215 +/-8 g）、4J组（210 +/-9 g）和8 J组（226 +/-9 g）在抗阻运动回合期间的负荷功相似。先前的LLLT并没有引起攀登性能的改善，但暴露于4J辐射导致较低的血乳酸水平运动后。4J剂量降低运动后肌酸激酶和乳酸脱氢酶水平，与应用时间无关。此外，4-J照射暴露显着衰减肿瘤坏死因子α，白细胞介素-6，白细胞介素-1，姜黄素诱导的中性粒细胞趋化因子-1，单核细胞趋化蛋白-1。在4J暴露的大鼠中有轻微的巨噬细胞肌肉浸润。这些数据表明，在阻力运动之前或之后进行LLLT可以减少肌肉损伤和炎症，从而改善肌肉恢复。我们试图确定一个理想的LLLT剂量合适的结果，其中4J照射暴露显示出显着的保护作用。
We investigated whether low-level laser therapy (LLLT) prior to or post resistance exercise could attenuate muscle damage and inflammation. Female Wistar rats were assigned to non-LLLT or LLLT groups. An 830-nm DMC Laser Photon III was used to irradiate their hind legs with 2J, 4J, and 8J doses. Irradiations were performed prior to or post (4J) resistance exercise bouts. Resistance exercise consisted of four maximum load climbs. The load work during a resistance exercise bout was similar between Control (non-LLLT, 225 +/- 10g), 2J (215 +/- 8g), 4J (210 +/- 9g), and 8J (226 +/- 9g) groups. Prior LLLT did not induce climbing performance improvement, but exposure to 4J irradiation resulted in lower blood lactate levels post-exercise. The 4J dose decreased creatine kinase and lactic dehydrogenase levels post-exercise regardless of the time of application. Moreover, 4-J irradiation exposure significantly attenuated tumor necrosis factor alpha, interleukin-6, interleukin-1, cytokine-induced neutrophil chemoattractant-1, and monocyte chemoattractant protein-1. There was minor macrophage muscle infiltration in 4J-exposed rats. These data indicate that LLLT prior to or post resistance exercise can reduce muscle damage and inflammation, resulting in muscle recovery improvement. We attempted to determine an ideal LLLT dose for suitable results, wherein 4J irradiation exposure showed a significant protective role.