LncRNA Gm12840 mediates WISP1 to regulate ischemia-reperfusion-induced renal fibrosis by sponging miR-677-5p
LncRNA Gm12840 mediates WISP1 to regulate ischemia-reperfusion-induced renal fibrosis by sponging miR-677-5p
复制标题
LncRNA Gm12840 通过海绵 miR-677-5p 介导 WISP1 调节缺血再灌注诱导的肾纤维化
DOI：
10.2217/epi-2020-0054
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发表时间：
2020-12-22
期刊：
影响因子：
3.8
通讯作者：
Zhou, Jun
中科院分区：
文献类型：
--
作者：
Chen, Hongtao;Fan, Youling;Zhou, Jun
Aim: We aimed to identify that long noncoding RNAs (lncRNAs) are involved in ischemia-reperfusion (IR)-induced late fibrosis of kidney and may constitute novel therapeutic strategies for acute kidney injury-induced chronic kidney disease. Materials & methods: We performed the mouse model of IR later induced renal fibrosis and analyzed lncRNA profiles using second-generation sequencing during the pathogenesis. Results: The expression levels of 43 lncRNAs and 141 lncRNAs were respectively changed significantly 7 days and 2 weeks after IR treatment. Based on the correlation analysis of the differentially expressed genes, the interaction networks of lncRNAs, miRNAs and mRNA were structured. Conclusion: LncRNA (Gm12840) could act as a sponge for miR-677-5p to mediate fibroblast activation induced by TGF-beta 1 via the WISP1/PKB (Akt) signaling pathway.
