Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading.
Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading.
复制标题
Cdc42 抑制剂 secramine A 的大规模合成及其对细胞扩散的抑制。
DOI：
10.1039/b609143a
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发表时间：
2006
影响因子：
3.2
通讯作者：
Hammond,GeraldB
中科院分区：
文献类型：
--
作者：
Xu,Bo;Pelish,Henry;Kirchhausen,Tomas;Hammond,GeraldB
我们描述了一个大规模合成secramine A。与其抑制小GTdR Cdc42激活的能力一致，我们发现secramine A抑制细胞扩散，这一过程先前被证明是Cdc42依赖性的。
We describe a large scale synthesis of secramine A. Consistent with its ability to inhibit activation of the small GTPase Cdc42, we find that secramine A inhibits cell spreading, a process previously shown to be Cdc42-dependent.