Endothelium and inelastic arteries: an early marker of vascular dysfunction in non-insulin dependent diabetes
Endothelium and inelastic arteries: an early marker of vascular dysfunction in non-insulin dependent diabetes
复制标题
内皮和非弹性动脉：非胰岛素依赖型糖尿病血管功能障碍的早期标志
DOI：
10.1136/bmj.312.7033.744
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
A. Henderson
中科院分区：
文献类型：
--
作者：
J. Goodfellow;M. Ramsey;L. Luddington;Christopher J. H. Jones;Phillip A Coates;F. Dunstan;M. Lewis;D. Owens;A. Henderson
动脉粥样硬化是非胰岛素依赖型糖尿病患者死亡和发病的主要原因。内皮功能障碍是动脉粥样硬化形成的基础。血流介导的血管扩张是内皮功能的一种测量，也是动脉扩张性的决定因素，1以前在非胰岛素依赖型糖尿病患者中还没有报道过这种测量。
我们研究了12例无症状、不吸烟、健康且控制良好的非胰岛素依赖型糖尿病患者(6名男性)，年龄1-7岁(平均3.8岁)，平均年龄50岁(SD9)，体重指数26.9(4.8)kg/m2，血清胆固醇浓度5.8(0.5)mmol/L。排除了内皮功能障碍的已知原因的患者。所有患者均有胰岛素抵抗伴基础高胰岛素血症，2无肾损害生化证据，无微量白蛋白尿。12名正常不吸烟的受试者在性别、年龄、体重指数、血液…等方面进行匹配
Atheroma is the main cause of mortality and morbidity in patients with non-insulin dependent diabetes mellitus. Endothelial dysfunction underlies atheroma formation. Flow mediated vasodilatation is a measure of endothelial function as well as a determinant of arterial distensibility,1 measurements of which have not previously been reported in patients with non-insulin dependent diabetes.
We studied 12 symptom free, non-smoking, healthy patients (six men) with well controlled non-insulin dependent diabetes diabnosed 1-7 (mean 3.8) years previously (mean age 50 (SD 9) years, body mass index 26.9 (4.8) kg/m2, serum cholesterol concentration 5.8 (0.5) mmol/l). Patients with known causes of endothelial dysfunction were excluded. All patients had insulin resistance with basal hyperinsulinaemia,2 no biochemical evidence of renal impairment, and no microalbuminuria. A group of 12 normal non-smoking subjects was matched for sex, age, body mass index, blood …