REQUIREMENT OF MIP-1-ALPHA FOR AN INFLAMMATORY RESPONSE TO VIRAL-INFECTION
REQUIREMENT OF MIP-1-ALPHA FOR AN INFLAMMATORY RESPONSE TO VIRAL-INFECTION
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DOI：
10.1126/science.7667639
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发表时间：
1995-09-15
期刊：
影响因子：
56.9
通讯作者：
SMITHIES, O
中科院分区：
文献类型：
--
作者：
COOK, DN;BECK, MA;SMITHIES, O
巨噬细胞炎症蛋白-1 α (MIP-1 α)是一种在体外具有促炎和干细胞抑制活性的趋化因子。在编码MIP-1 α的基因被破坏的小鼠中，研究了其在体内的生物学作用。纯合子MIP-1 α突变（-/-）小鼠对感染野生型（+/+）小鼠的柯萨奇病毒诱导的心肌炎具有抗性。流感病毒感染的-/-小鼠与感染的+/+小鼠相比，肺炎减少，病毒清除延迟。-/-小鼠没有明显的造血异常。这些结果表明MIP-1 α是体内病毒诱导炎症的重要介质。
Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wildtype (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo.