Anticancer properties for 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007)/3,7-diaminophenothiazin-5-ium double salts.
Anticancer properties for 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007)/3,7-diaminophenothiazin-5-ium double salts.
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4,4-二羟基二苯甲酮-2,4-二硝基苯腙 (A-007)/3,7-二氨基吩噻嗪-5-鎓复盐的抗癌特性。
DOI：
10.1016/s0960-894x(01)00408-5
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发表时间：
2001
影响因子：
2.7
通讯作者：
Cole,RB
中科院分区：
文献类型：
--
作者：
Morgan,LR;Rodgers,AH;LeBlanc,BW;Boué,SM;Yang,Y;Jursic,BS;Cole,RB
4,4′-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) formed stable double salts with phenothiazin-5-ium salts (2a–d), which have improved in vitro anticancer activities, as compared to A-007 alone. The stable salt between methylene blue (2a) and A-007 allowed the latter to diffuse into the dermis layers of skin. It is anticipated that these new salts will allow A-007 to penetrate into the deep lymphatic/vascular channels of the dermis, which contain metastatic cancer cells, and improve in vivo anticancer activities.
