MOLECULAR-BASES OF THE ACUTE CORONARY SYNDROMES
MOLECULAR-BASES OF THE ACUTE CORONARY SYNDROMES
复制标题
DOI：
10.1161/01.cir.91.11.2844
复制
发表时间：
1995-06-01
期刊：
影响因子：
37.8
通讯作者：
LIBBY, P
中科院分区：
文献类型：
--
作者：
LIBBY, P
急性冠状动脉综合征包括不稳定型心绞痛和急性心肌梗死，是目前临床心脏病学的主要关注点。这个世纪见证了我们对这些综合征的临床概念的显著演变。Herrick 1描述了世纪初急性冠状动脉血栓形成患者的生存情况。在本世纪的前半叶，心电图的引入导致了急性心肌梗死定义的重大临床进展，并为现代冠状动脉护理提供了基础;在本世纪的后半叶，冠状动脉造影术的出现允许在活体患者中定义由于动脉粥样硬化引起的冠状动脉狭窄。这种诊断技术的引入使得合理的治疗方式得以发展，如冠状动脉搭桥手术和随后的经皮腔内冠状动脉成形术。直到最近，我们似乎已经对人类冠状动脉疾病的病理生理学有了坚定的理解，并为其主要表现设计了适当的治疗模式。然而，最近的临床数据表明，我们仍然有很多了解的病理生理学的急性冠状动脉综合征。
The acute coronary syndromes, including unstable angina and acute myocardial infarction, currently constitute a major preoccupation of clinical cardiology. This century has witnessed a remarkable evolution in our clinical concepts of these syndromes. Herrick 1 described the survival of patients with acute coronary thrombosis early in the century. The introduction of the ECG led to major clinical advances in the definition of acute myocardial infarction during the first half of this century and furnished the basis of modern coronary care.In the latter half of this century, the advent of coronary arteriography permitted definition in the living patient of coronary stenoses due to atherosclerosis. The introduction of this diagnostic technique allowed the development of rational treatment modalities such as coronary artery bypass surgery and, subsequently, percutaneous transluminal coronary angioplasty. Until recently, it seemed that we had achieved a firm understanding of the pathophysiology of human coronary artery disease and had devised appropriate modes of therapy for its major manifestations. Yet, recent clinical data suggest that we still have much to learn about the pathophysiology of the acute coronary syndromes.