Cerebellar atrophy in temporal lobe epilepsy
Cerebellar atrophy in temporal lobe epilepsy
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DOI：
10.1016/j.yebeh.2005.05.022
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发表时间：
2005-09-01
影响因子：
2.6
通讯作者：
Seidenberg, M
中科院分区：
文献类型：
--
作者：
Hermann, BP;Bayless, K;Seidenberg, M
目的。这项工作的目的是确定慢性颞叶癫痫小脑萎缩的存在和程度，其临床发作的相关性，以及它与一般皮质萎缩的关系。研究对象是78名颞叶癫痫患者和63名年龄和性别匹配的健康对照组。所有受试者都进行了高分辨率MRI，并对小脑进行了手动追踪。通过结构化访谈和查阅病历获得临床发作特征和病史。癫痫组表现出小脑体积明显异常，根据调整，平均减少幅度为4%至6.6%。在包括z在内的所有操作定义或异常阈值中，癫痫患者表现出小脑萎缩的个体明显多于对照组
Purpose. The goal of this work was to determine the presence and degree of cerebellar atrophy in chronic temporal lobe epilepsy, its clinical seizure correlates, and its association with general cortical atrophy.Methods. Study participants were 78 persons with temporal lobe epilepsy and 63 age- and gender-matched healthy controls. All subjects underwent high-resolution MRI with manual tracing of the cerebellum. Clinical seizure features and history were obtained by structured interview and review of medical records.Results. The epilepsy group exhibited significant abnormality in cerebellar volume, with mean reductions ranging from 4 to 6.6% depending on adjustments. Significantly more individual subjects with epilepsy exhibited cerebellar atrophy compared with controls across all operational definitions or thresholds of abnormality including z