Characteristic X-ray imaging for palliative therapy using strontium-89 chloride: understanding the mechanism of nuclear medicine imaging of strontium-89 chloride
Characteristic X-ray imaging for palliative therapy using strontium-89 chloride: understanding the mechanism of nuclear medicine imaging of strontium-89 chloride
复制标题
使用 89 氯化锶进行姑息治疗的特征 X 射线成像：了解 89 氯化锶的核医学成像机制
DOI：
10.1007/s12194-016-0388-8
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发表时间：
2017
影响因子：
1.6
通讯作者：
Masahiro Fukushi
中科院分区：
文献类型：
--
作者：
Yoshiki Owaki;Kazumasa Inoue;Hiroto Narita;Keisuke Tsuda;Masahiro Fukushi
锶-89氯化锶是一种可重复给药的靶向姑息疗法，可用于疼痛的骨转移，其在各种原发肿瘤的骨转移中的有效性已有报道。然而，疼痛缓解治疗的有效性仅用视觉模拟评分等主观指标来描述，缺乏客观性。尽管已经报道了利用核医学成像对70-80keV左右的能量峰进行量化锶-89氯化物治疗有效性的各种尝试，但还没有解释锶-89氯化物成像的原理。本研究以基础性研究为基础，对锶-氯化物的核医学成像原理进行了评价。此外，还对获取锶-89氯化物图像数据的最佳准直器进行了评价。根据这一结果，解释了锶-89氯化物核医学成像的原理：能量峰是在锶-89氯化物溶液的制造过程中包括的从锶-85发出的514keV的伽马射线与成像所用的铅准直器相互作用产生的特征X射线。确定了高效产生特征X射线的最佳准直器为中高能准直器。
Strontium-89 (Sr-89) chloride is a targeted palliative therapy used for painful bone metastasis in which repeated doses can be administered, and its usefulness has been reported in the case of bone metastasis of various primary tumors. However, the effectiveness of the pain relief treatment is only described using a subjective index such as the visual analog scale, which lacks objectivity. Although various attempts at quantifying the effectiveness of Sr-89 chloride therapy have been reported using nuclear medicine imaging for energy peaks around 70–80 keV, the principle of Sr-89 chloride imaging has not been explained. In this study, the principle of nuclear medicine imaging for Sr-89 chloride was evaluated using a fundamental study. Additionally, the optimal collimator for acquiring Sr-89 chloride image data was evaluated. Based on the results, the principle of nuclear medicine imaging for Sr-89 chloride could be explained: the energy peaks were characteristic X-rays produced by interactions between gamma rays (514 keV) emitted from Sr-85, which is included during the manufacturing process of the Sr-89 chloride solution, and the lead collimator used in the imaging. The optimal collimator for generating characteristic X-rays efficiently was identified as a middle-to-high energy collimator.
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