Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination.
Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination.
复制标题
DOI：
10.1038/s41586-021-04060-7
复制
发表时间：
2021-12
期刊：
影响因子：
64.8
通讯作者：
Nussenzweig MC
中科院分区：
文献类型：
--
作者：
Cho A;Muecksch F;Schaefer-Babajew D;Wang Z;Finkin S;Gaebler C;Ramos V;Cipolla M;Mendoza P;Agudelo M;Bednarski E;DaSilva J;Shimeliovich I;Dizon J;Daga M;Millard KG;Turroja M;Schmidt F;Zhang F;Tanfous TB;Jankovic M;Oliveria TY;Gazumyan A;Caskey M;Bieniasz PD;Hatziioannou T;Nussenzweig MC
严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染会产生B细胞反应，并持续演变至少一年。在此期间，记忆B细胞表达越来越广泛和有效的抗体，这些抗体对所关注的变异中发现的突变具有抵抗力。因此，用目前可用的信使核糖核酸疫苗接种2019年冠状病毒病(新冠肺炎)康复期个体可产生针对所有测试变种的高水平血浆中和活性。在这里，我们在一组SARS-CoV-2幼稚个体中检测了接种现代(mRNA-1273)或辉瑞-BioNTech(BNT162b2)mRNA疫苗五个月后记忆B细胞的进化。在原始期和增强期之间，记忆B细胞会产生抗体，从而增强中和活性，但此后效力或广度不会进一步增加。相反，在幼稚个体接种疫苗五个月后出现的记忆B细胞表达的抗体与主导初始反应的抗体相似。虽然随着时间的推移，自然感染选择的个体记忆抗体比疫苗诱导的抗体具有更大的效力和广度，但接种疫苗后，血浆的总体中和效力更大。这些结果表明，用目前可用的mRNA疫苗加强接种的人将增加血浆中和活性，但可能不会产生与接种恢复期的人相同广度的抗体。随着时间的推移，自然感染SARS-CoV-2的个体记忆抗体比接种疫苗产生的抗体具有更强的效力和广度，而接种疫苗后血浆的总体中和能力更强。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces B cell responses that continue to evolve for at least a year. During that time, memory B cells express increasingly broad and potent antibodies that are resistant to mutations found in variants of concern. As a result, vaccination of coronavirus disease 2019 (COVID-19) convalescent individuals with currently available mRNA vaccines produces high levels of plasma neutralizing activity against all variants tested. Here we examine memory B cell evolution five months after vaccination with either Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) mRNA vaccine in a cohort of SARS-CoV-2-naive individuals. Between prime and boost, memory B cells produce antibodies that evolve increased neutralizing activity, but there is no further increase in potency or breadth thereafter. Instead, memory B cells that emerge five months after vaccination of naive individuals express antibodies that are similar to those that dominate the initial response. While individual memory antibodies selected over time by natural infection have greater potency and breadth than antibodies elicited by vaccination, the overall neutralizing potency of plasma is greater following vaccination. These results suggest that boosting vaccinated individuals with currently available mRNA vaccines will increase plasma neutralizing activity but may not produce antibodies with equivalent breadth to those obtained by vaccinating convalescent individuals. Individual memory antibodies selected over time by natural infection with SARS-CoV-2 have greater potency and breadth than antibodies elicited by vaccination, whereas the overall neutralizing potency of plasma is greater following vaccination.
登录
查看更多内容
影响因子：
32.4
作者：
Dugan HL;Stamper CT;Li L;Changrob S;Asby NW;Halfmann PJ;Zheng NY;Huang M;Shaw DG;Cobb MS;Erickson SA;Guthmiller JJ;Stovicek O;Wang J;Winkler ES;Madariaga ML;Shanmugarajah K;Jansen MO;Amanat F;Stewart I;Utset HA;Huang J;Nelson CA;Dai YN;Hall PD;Jedrzejczak RP;Joachimiak A;Krammer F;Diamond MS;Fremont DH;Kawaoka Y;Wilson PC
通讯作者：
Wilson PC
影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
DOI：
10.1056/nejmoa2034545
发表时间：
2021-02-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lumley SF;O'Donnell D;Stoesser NE;Matthews PC;Howarth A;Hatch SB;Marsden BD;Cox S;James T;Warren F;Peck LJ;Ritter TG;de Toledo Z;Warren L;Axten D;Cornall RJ;Jones EY;Stuart DI;Screaton G;Ebner D;Hoosdally S;Chand M;Crook DW;O'Donnell AM;Conlon CP;Pouwels KB;Walker AS;Peto TEA;Hopkins S;Walker TM;Jeffery K;Eyre DW;Oxford University Hospitals Staff Testing Group
通讯作者：
Oxford University Hospitals Staff Testing Group
影响因子：
32.4
作者：
Halliley JL;Tipton CM;Liesveld J;Rosenberg AF;Darce J;Gregoretti IV;Popova L;Kaminiski D;Fucile CF;Albizua I;Kyu S;Chiang KY;Bradley KT;Burack R;Slifka M;Hammarlund E;Wu H;Zhao L;Walsh EE;Falsey AR;Randall TD;Cheung WC;Sanz I;Lee FE
通讯作者：
Lee FE
影响因子：
24.8
作者：
Goel RR;Apostolidis SA;Painter MM;Mathew D;Pattekar A;Kuthuru O;Gouma S;Hicks P;Meng W;Rosenfeld AM;Dysinger S;Lundgreen KA;Kuri-Cervantes L;Adamski S;Hicks A;Korte S;Oldridge DA;Baxter AE;Giles JR;Weirick ME;McAllister CM;Dougherty J;Long S;D'Andrea K;Hamilton JT;Betts MR;Luning Prak ET;Bates P;Hensley SE;Greenplate AR;Wherry EJ
通讯作者：
Wherry EJ