Regional oxygenation and radiotherapy: a study of the degradation of infused hydrogen peroxide. II. Measurement of decomposition of H2O2 infused into flowing blood.
Regional oxygenation and radiotherapy: a study of the degradation of infused hydrogen peroxide. II. Measurement of decomposition of H2O2 infused into flowing blood.
复制标题
区域氧合和放射治疗：注入过氧化氢降解的研究。
DOI：
10.1080/09553007114550561
复制
发表时间：
1971
期刊：
影响因子：
--
通讯作者：
J. I. MacNaughton
中科院分区：
文献类型：
--
作者：
J. I. MacNaughton
在各种条件下测量了注入模型系统中流动的血液中的过氧化氢的分解程度。结果表明：（1）注入的过氧化氢可能倾向于流动，而不是混合。在输注点没有明显的湍流迹象，这将有助于混合。(2)分解比以前认为的要慢。(3)在临床情况下，流体动力学因素使得不可能精确测定pO 2。(4)游离过氧化物灌注肿瘤组织的可能性高。(5)在动脉内灌注过氧化氢时，在相关时间内，只有血浆过氧化氢酶参与分解过程。(6)在这些实验条件下，过氧化氢酶-过氧化氢反应的半衰期约为0.35秒，提出了一种“过氧化氢效应”，它与“氧效应”相当，但比“氧效应”更强，并根据这一假设对早期工作者的实验研究进行了评述。
SummaryThe degree of decomposition of hydrogen peroxide infused into blood flowing in a model system has been measured under various conditions. The results show:(1) that infused peroxide probably tends to stream, and not mix. There is no evidence of marked turbulence at the infusion point which would assist mixing.(2) decomposition is slower than previously believed.(3) in the clinical situation, hydrodynamic factors make precise determination of the pO2 impossible.(4) the probability that free peroxide perfuses tumour tissue is high.(5) in intra-arterial peroxide infusion, only plasma catalase is involved, in the relevant time, in the decomposition process.(6) a half time for catalase-peroxide reaction of approximately 0·35 sec under the conditions of these experiments.A ‘peroxide effect’, comparable to but more potent than the ‘oxygen effect’, is postulated, and experimental studies of earlier workers are reviewed in the light of this postulate.